Results 81 to 90 of about 55,874 (301)

A Phase 1, Randomized, Placebo‐Controlled, Multiple‐Dose, Double‐Blind Study to Evaluate and Compare the Pharmacokinetics and Safety of Rimegepant in Healthy Adult Japanese and Caucasian Individuals

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This Phase 1, randomized, placebo‐controlled, double‐blind study assessed the pharmacokinetic profile of rimegepant (25, 75, or 150 mg once daily for 14 days) in healthy Japanese and Caucasian adults. Exposures were modestly increased in Japanese participants compared with Caucasian participants following a single dose of rimegepant (Day 1 ...
Rajinder Bhardwaj, Chay Ngee Lim, Yinhua Li, Kyle T. Matschke, Richard Bertz, Robert Croop, Jing Liu   +6 more
wiley   +1 more source

TACHY-DEPENDENT DISPERSION OF QT INTERVAL AND INTRAVENTRICULAR CONDUCTIVITY DISTURBANCES: CLINICOINSTRUMENTAL PARALLELS

Российский кардиологический журнал, 2010
In 28 patients with intraventricular block and coronary heart disease (CHD), as well as in 20 professional ex-athletes with impaired intraventricular conductivity, corrected QT interval dispersion at maximal and minimal heart rate (HR) was assessed ...
Yu. N. Fedulaev, O. S. Fedoseeva, G. A. Khayretdinova, O. V. Reyner   +3 more
doaj  

QT Interval Revisited —Not Just the Matter of “Interval,” but “Dynamics, Variability and Morphology” Matter!—

Journal of Arrhythmia, 2007
Recently, the effects of QT interval prolongation have received more attention among clinicians, industry, and official regulatory agencies. Some have advocated the total elimination or discontinuing development of drugs which prolong the QT interval. In
Tetsunori Saikawa, MD, Mikiko Nakagawa, MD, Naohiko Takahashi, MD   +2 more
doaj   +1 more source

Screening for QT Prolongation in the Emergency Department: Is There a Better “Rule of Thumb?” [PDF]

, 2020
Introduction: Identification of QT prolongation in the emergency department (ED) is critical for appropriate monitoring, disposition, and treatment of patients at risk for torsades de pointes (TdP).
Friedman, Ari B., Rischall, Megan L., Smith, Stephen W.   +2 more
core  

The role of Volatile Anesthetics in Cardioprotection: a systematic review. [PDF]

, 2012
This review evaluates the mechanism of volatile anesthetics as cardioprotective agents in both clinical and laboratory research and furthermore assesses possible cardiac side effects upon usage.
Applegate, Richard L, Krafft, Paul R, Leitzke, Arthur S, Tang, Jiping, Van Allen, Nicole R, Zhang, John H   +5 more
core   +1 more source

Major Adverse Cardiac Events with Ondansetron: A Systematic Review

Clinical Pharmacology &Therapeutics, EarlyView.
Evidence base: 170 randomized trials, 23,421 adults, predominantly single‐dose IV ondansetron, mean follow‐up 20 days. Observed outcomes: Major adverse cardiac events were rare, no ventricular arrhythmias or torsades de pointes observed. Conclusion: Ondansetron was not associated with increased mortality or serious cardiac arrhythmias in adult ...
Michael Cristian Garcia, Bhavya Gandhi, Faisal Quadri, Mahnoor Shahab, Kassie Rong, Genevieve Ramnarine, Ishleen Sudan, Sophia Zhang, Michelle Yu, Sara Mojdehi, Lawrence Mbuagbaw, Anne M. Holbrook   +11 more
wiley   +1 more source

Electrocardiogram characteristics and possible associated factors in healthy Japanese children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

BMC Pediatrics
Background The number of young patients with cardiac disease has recently increased. To describe the electrocardiogram characteristics and identify the possible factors affecting the characteristics in early life might be helpful for the prevention and ...
Shingo Nakashima, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Taku Obara, Shinichi Kuriyama   +8 more
doaj   +1 more source

A randomized, double‐blind, placebo‐ and positive‐controlled crossover study of the effects of durlobactam on cardiac repolarization in healthy subjects

Clinical and Translational Science, 2021
Durlobactam (formerly ETX2514) is a diazabicyclooctane β‐lactamase inhibitor that inhibits class A, C, and D β‐lactamases. Sulbactam combined with durlobactam has in vitro and in vivo activity against Acinetobacter baumannii including carbapenem‐ and ...
John O’Donnell, Kathleen Maloney, Melissa Steidler, Royce Morrison, Robin Isaacs   +4 more
doaj   +1 more source

Incidencia de QT corto y largo en alumnos de primer ingreso a Facultad de Deportes [PDF]

, 2015
Las alteraciones electrocardiográficas del intervalo QT (síndrome de QT corto y largo) están asociadas a un riesgo elevado de muerte súbita por arritmias ventriculares malignas y a episodios de fibrilación auricular.
Arce Guridi, Raquel Citlalli, Chávez López, Carlos Alberto, Galarraga Triana, Edgar Ney, Pineda Espejel, Heriberto Antonio, Trejo Trejo, Marina   +4 more
core  

Cardiorespiratory cross‐frequency coupling biomarker for sudden unexpected death in epilepsy

Epilepsia, EarlyView.
Abstract Objective Sudden unexpected death in epilepsy (SUDEP) often follows generalized tonic–clonic seizures during sleep, likely resulting from impaired brainstem cardiorespiratory function. We used ictal electrocardiogram (ECG)‐based cross‐frequency phase–amplitude coupling (PAC) to detect cardiorespiratory disruptions, comparing SUDEP to non‐SUDEP
Adam C. Gravitis, Richard Wennberg, Peter L. Carlen, Yotin Chinvarun, Victor Lira, Juliana Laze, Orrin Devinsky, Berj L. Bardakjian   +7 more
wiley   +1 more source