Results 61 to 70 of about 1,303,482 (284)

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Accelerating Discovery of Organic Molecular Crystals via Materials Informatics and Autonomous Experiments

Advanced Intelligent Discovery, EarlyView.
Materials informatics and autonomous experimentation are transforming the discovery of organic molecular crystals. This review presents an integrated molecule–crystal–function–optimization workflow combining machine learning, crystal structure prediction, and Bayesian optimization with robotic platforms.
Takuya Taniguchi, Kazuki Ishizaki, Ryo Fukasawa   +2 more
wiley   +1 more source

Methods of Assessment and Clinical Relevance of QT Dynamics [PDF]

, 2005
The dependence on heart rate of the QT interval has been investigated for many years and several mathematical formulae have been proposed to describe the QT interval/heart rate (or QT interval/RR interval) relationship. While the most popular is Bazett’s
Agata, Musialik-Lydka, Beata, Sredniawa, Piotr, Jarski, Anna, Sliwinska, Zbigniew, Kalarus   +4 more
core  

Determination of Corrected QT Interval in Kangal Breed Dogs

, 2019
QT interval is one of the important reasons of severe and life threatening ventricular arrhythmias in humans and animals Many formulas have been developed for correcting the QT interval however the best formula did not define yet by the researchers.
Or, M. E., Gonul, Remzi, YILDIZ, Kübra, Koenhemsi, Lora   +3 more
core   +1 more source

Genotype–Phenotype Correlations of Monoallelic PFIC Variants in Pediatric Liver Disease: A Multicenter Retrospective Cohort Study

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Progressive familial intrahepatic cholestasis (PFIC) is classically caused by biallelic pathogenic variants, yet monoallelic variants of uncertain significance (VUS) in PFIC‐associated genes are increasingly identified in children with cholestasis, creating diagnostic uncertainty.
Brett J. Hoskins, Tiziano Pramparo, Chaowapong Jarasvaraparn, Michael J. Wilsey, Voytek Slowik, Lakshmi Kunam, Janis M. Stoll, Ruben E. Quiros‐Tejeira, Simon Lam, Wikrom Karnsakul   +9 more
wiley   +1 more source

Drug-induced prolonged corrected QT interval in patients with methadone and opium overdose

Substance Abuse Treatment, Prevention, and Policy, 2019
Background Iran is a country with the highest rate of opioid addiction in the world. The most commonly used opioid in Iran is opium, and methadone is in second place. The trend of drug use has changed from opium to methadone from 2006 to 2011.
Davood Soroosh, Mahbubeh Neamatshahi, Bahram Zarmehri, Samaneh Nakhaee, Omid Mehrpour   +4 more
doaj   +1 more source

The integrated Lei‐CNS PBPK‐PD model effectively predicts clozapine brain disposition and D2 receptor occupancy in humans

British Journal of Clinical Pharmacology, EarlyView.
Aim Clozapine, used for treatment‐resistant schizophrenia, has a narrow therapeutic window and highly variable plasma pharmacokinetics (PK), necessitating careful monitoring. Direct measurement of unbound brain PK in humans is unethical. To develop a physiologically based pharmacokinetic–pharmacodynamic (PBPK‐PD) model to predict clozapine brain ...
Mengxu Zhang, Thomas I. F. H. Cremers, Vivi Rottschäfer, Elizabeth C. M. de Lange   +3 more
wiley   +1 more source

Altered circadian rhythmicity of the QT interval predicts mortality in a large real-world academic hospital population

Heliyon
Objective and rationale: Small studies have shown that the QT interval follows a circadian rhythm. This finding has never been confirmed in a large real-world hospital population and the clinical meaning of disrupted rhythmicity remains unknown. Methods:
Rutger R. van de Leur, Bastiaan C. du Pré, Markella I. Printezi, Rutger J. Hassink, Pieter A. Doevendans, René van Es, Linda W. van Laake   +6 more
doaj   +1 more source

Electrocardiogram with prolonged QT interval in Gitelman disease [PDF]

, 2002
Electrocardiogram with prolonged QT interval in Gitelman disease.BackgroundPotassium and magnesium deficiency prolong the QT interval on a standard electrocardiogram and predispose the patient to dangerous cardiac arrhythmias. No information is available
Edefonti, Alberto, Tosetto, Camillo, Colussi, Giacomo, Bianchetti, Mario G., Bettinelli, Alberto, Tommasini, Ginaluca   +5 more
core   +1 more source

Scaffolding a Low‐Cost Experiential Bioreactor Module: Reducing Cognitive Load to Enhance Competency and Self‐Efficacy

Biochemistry and Molecular Biology Education, EarlyView.
ABSTRACT Low‐cost experiential modules are critical for democratizing biotechnology education, yet most undergraduates lack hands‐on experience with continuous‐culture bioreactor operations, which are fundamental to industrial bioprocessing. This study employed design‐based research across two iterative cycles (Fall 2024, n = 8; Fall 2025, n = 11) to ...
Russell K. Pirlo, Matthew Lopper, Justin C. Biffinger   +2 more
wiley   +1 more source