Results 51 to 60 of about 1,303,482 (284)

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Mesoporous PU/PEDOT:PSS Electrodes Reveal Population‐Level Stochastic Bioelectrical Dynamics in Marine Diatoms

Advanced Science, EarlyView.
Mesoporous mixed ionic‐electronic PU/PEDOT: PSS electrodes enable label‐free detection of stochastic extracellular bioelectrical dynamics in living Phaeodactylum tricornutum. Living diatoms actively modulate interfacial ionic dynamics, establishing stochastic electrochemical noise as a sensitive probe of microbial bioelectrochemical activity and a new ...
David M. S. Silva, Felipe L. Bacellar, Raquel Amaral, Louis‐Josselin Lavier‐Aydat, Luísa Cortes, Kamal Asadi, Leïla Tirichine, Paulo R. F. Rocha   +7 more
wiley   +1 more source

The importance of the epinephrine provocation test for the hidden type-1 congenital long QT syndrome

Türk Kardiyoloji Derneği Arşivi, 2020
Congenital long QT syndrome (LQTS) is a genetic channelopathy associated with a high incidence of sudden cardiac death in children and young adults. QT interval prolongation is typically the primary finding on the electrocardiography (ECG) recordings ...
Adem Atici, Ramazan Asoğlu, Hasan Ali Barman, Irfan Sahin   +3 more
doaj   +1 more source

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

Comparison of Corrected QT Interval Prolongation in Young and Middle-aged Adults after First-time ST-Elevation Myocardial Infarction at Cardiac Care Facility: A Cross-Sectional Study

Life and Science
Objective: To compare corrected QT interval prolongation in young and middle-aged adults after first-time ST-elevation myocardial infarction and to determine its association with selected clinical variables. Study Design: Analytical cross-sectional study.
Arif Khaliq, Mohsin Saif, Sidra Saif, Waheed Ur Rehman, Riaz Haider, Tahir Zaman   +5 more
doaj   +1 more source

Congenital Short QT Syndrome [PDF]

, 2004
Long QT intervals in the ECG have long been associated with sudden cardiac death. The congenital long QT syndrome was first described in individuals with structurally normal hearts in 1957.1 Little was known about the significance of a short QT interval.
Antzelevitch, Charles, Johnson Francis, Francis, Johnson, Charles Antzelevitch   +3 more
core  

Association between C-reactive protein, corrected QT interval and presence of QT prolongation in hypertensive patients [PDF]

, 2014
C-reactive protein (CRP) and corrected QT (QTc) interval are predictors of cardiovascular disease. Whether CRP is associated with QTc interval and QT prolongation is unknown in hypertensive patients.
Hsu, Po-Chao, Lee, Wen-Hsien, Wen-Ter Lai, Chang, Kai-Ting, Lai, Wen-Ter, Kai-Ting Chang, Tsung-Hsien Lin, Po-Chao Hsu, Su, Ho-Ming, Voon, Wen-Chol, Wen-Chol Voon, Wen-Hsien Lee, Sheu, Sheng-Hsiung, Ho-Ming Su, Shu, Hsu-Shien, Sheng-Hsiung Sheu, Chu, Chun-Yuan, Lin, Tsung-Hsien, Hsu-Shien Shu, Chun-Yuan Chu   +19 more
core   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Estimation of cardiac QTc intervals in people prescribed antipsychotics: a comparison of correction factors

Therapeutic Advances in Psychopharmacology, 2022
Background: A prolonged electrocardiogram (ECG) QT interval is associated with cardiac events and increased mortality. Antipsychotics can prolong the QT interval.
Teodora Andric, Karl Winckel, Timothy David Tanzer, Samantha Hollingworth, Lesley Smith, Katherine Isoardi, Olivier Tan, Dan Siskind   +7 more
doaj   +1 more source

Findings of the corrected QT interval.

, 2014
Patients with orthostatic hypotension (OH) had a more prolonged corrected QT (QTc) interval (448.8±33.6 msec) than patients with neurocardiogenic syncope (NCS) (429.1±24.6 msec, p = 0.001) and postural orthostatic tachycardia syndrome (POTS) (421.7±28.6 ...
Dong-Hyuk Cho (624550), Jin-Woo Park (624549), Jung Bin Kim (624547), Soonwoong Hong (624548), Ki-Jong Park (624551), Byung-Jo Kim (624552)   +5 more
core   +1 more source