Results 51 to 60 of about 52,799 (238)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Reliability of the electrocardiogram in normal rats [PDF]

, 2012
Several electrocardiogram (ECG) indexes are used to identify cardiac abnormalities in rats. However, there are few studies about the reliability of this tool.
Areas, Miguel Arcanjo, Macedo, Denise Vaz de, Oliveira, Renato Buscariolli de, Santos, Gustavo Barbosa   +3 more
core   +1 more source

Transcranial direct current stimulation improves the QT variability index and autonomic cardiac control in healthy subjects older than 60 years [PDF]

, 2016
Background: Noninvasive brain stimulation technique is an interesting tool to investigate the causal relation between cortical functioning and autonomic nervous system (ANS) responses.
Di Iorio, Claudia, Fiorucci, Claudia, Magrì, Damiano, Mastropietri, Fabiola, Moscucci, Federica, Ottaviani, Cristina, Parrotta, Ilaria, Pascucci, Matteo, Petrocchi, Nicola, Piccirillo, Gianfranco   +9 more
core   +1 more source

Variability of heart rate correction methods for the QT interval [PDF]

British Journal of Clinical Pharmacology, 2003
Aims  To compare variability of heart rate‐corrected QT intervals (QTc) using three different methods in a study of low‐dose oral haloperidol.Methods  In a randomized, double‐blind, placebo‐controlled, crossover trial, we studied QT interval pharmacodynamics of single doses of oral haloperidol (10 mg) in 16 healthy subjects.
Mehul, Desai, Lang, Li, Zeruesenay, Desta, Marek, Malik, David, Flockhart   +4 more
openaire   +2 more sources

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Impact of hamstring versus quadriceps tendon graft on thigh muscle strength and surface electromyography activity after anterior cruciate ligament reconstruction

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To compare quadriceps tendon (QT) and hamstring tendon (HT) autografts regarding isometric thigh muscle strength, surface electromyography (sEMG) activity and clinical outcomes following anterior cruciate ligament reconstruction (ACLR).
Benjamin Forquignon, Tobias Drenck, Matthias Krause, Ralph Akoto, Karl‐Heinz Frosch, Götz Welsch, Alexander Korthaus, Grégoire Thürig, Dimitris Dalos   +8 more
wiley   +1 more source

Quadriceps tendon autograft is not inferior to bone‐patellar tendon‐bone or hamstring autograft in anterior cruciate ligament reconstruction in terms of subjective patient‐reported outcomes: Two‐year results of a multicenter randomised controlled study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To evaluate the effectiveness of quadriceps tendon (QT) compared to bone‐patellar tendon‐bone (BPTB) and hamstring tendon (HT) autografts in anterior cruciate ligament reconstruction (ACLR) regarding patient‐reported outcomes 2 years postoperatively.
Barbara C. Boer, Reinoud W. Brouwer, Judith olde Heuvel, Astrid J. de Vries, Wybren A. van der Wal, J. Christiaan Rompen, Albert H. van Houten, Roy A. G. Hoogeslag   +7 more
wiley   +1 more source

Screening for QT Prolongation in the Emergency Department: Is There a Better “Rule of Thumb?” [PDF]

, 2020
Introduction: Identification of QT prolongation in the emergency department (ED) is critical for appropriate monitoring, disposition, and treatment of patients at risk for torsades de pointes (TdP).
Friedman, Ari B., Rischall, Megan L., Smith, Stephen W.   +2 more
core  

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Detection of nocturnal hypoglycemic episodes (natural occurrence) in children with Type 1 diabetes using an optimal Bayesian neural network algorithm. [PDF]

, 2008
Hypoglycemia or low blood glucose is dangerous and can result in unconsciousness, seizures and even death. It is a common and serious side effect of insulin therapy in patients with diabetes.
Ghevondian, N, Jones, TW, Nguyen, HT
core