Results 81 to 90 of about 357,319 (266)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

INTELLECTUAL SENSOR SYSTEM OF SOIL LIGHT-COLOR CONTROL: REALIZATION OF SELF-SUSTAINABILITY FUNCTIONS

Наука и техника, 2011
An intellectual sensor module of soil light-color control designed for an accurate agriculture technology which comprises functions of self-diagnostics, self-corrections and self-attestation.
V. M. Koleshko, A. V. Gulay, V. A. Gulay, E. V. Polynkova   +3 more
doaj  

The effect of multimodal rehabilitation program on pain, functional outcomes, and plantar fascia thickness in patients with plantar fasciitis: a randomized controlled trial

BMC Musculoskeletal Disorders
Background Plantar fasciitis (PF) is characterized by heel pain and functional limitations, with hyperpronation identified as a primary risk factor. Mechanical correction of malalignment is one of several therapeutic options, but no one has settled on a ...
Mohamed Ramadan Ibraheem, Mohamed Ashraf Abd El-Moneim, Mona Mohamed Ibrahim   +2 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Corrective Exercise; Theraband Exercise; NASM; Water Resistance Training; Flat Foot

Journal of Ardabil University of Medical Sciences, 2021
Background & objectives: Flat foot is one of the most common physical and motor disorders among students. The aim of this study was to investigate the effects of three comprehensive corrective exercise protocols on the correction of flexible flat foot in
Abbas Mousavi, Allahyar Arabmomeni
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Provably Correct Control-Flow Graphs from Java Programs with Exceptions

, 2011
We present an algorithm to extract flow graphs from Java bytecode, focusing on exceptional control flows. We prove its correctness, meaning that the behaviour of the extracted control-flow graph is an over-approximation of the behaviour of the original program.
Amighi, A., de Carvalho Gomes, Pedro, Huisman, Marieke   +2 more
openaire   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Effectiveness of a digital-based gradual exercise training program for preventing relapse in congenital clubfoot: a protocol for a randomized controlled clinical trial

BMC Pediatrics
Background Congenital clubfoot (CCF) is characterized by foot deformity. The Ponseti method achieves anatomical correction through casting and orthotics, but there is a high probability of further recurrence before skeletal maturity. It is challenging to
Qimeng Fan, Xuan Zhou, Nan Chen, Juping Liang, Xin Li, Xiaoqing Zhu, Hong Yu, Xuan Yang, Qing Du   +8 more
doaj   +1 more source

Dynamic Modeling, Simulation, and Optimization of Vehicle Electronic Stability Program Algorithm Based on Back Propagation Neural Network and PID Algorithm

Actuators
The vehicle lateral stability control algorithm is an essential component of the electronic stability program (ESP), and its control effect directly affects the vehicle’s driving safety.
Zheng Wu, Cunfeng Kang, Borun Li, Jiageng Ruan, Xueke Zheng   +4 more
doaj   +1 more source