Results 91 to 100 of about 78,461 (306)

FEATURES OF THE DEVELOPMENT OF HEALTH AND SOCIAL SECURITY OF SOVIET PRISONERS IN INSTITUTIONS OF CONFINEMENT IN 1956-1991

open access: yesГуманитарные и юридические исследования, 2021
The article studies actual problems of domestic and medical support of Soviet convicts that served sentences in correctional institutions in 1956-1991, when the system of correctional labor colonies was developed and functioning instead of the previously
Dmitry Yushchenko
doaj  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Professionalism in the Alaska Department of Corrections: Education and Experience [paper] [PDF]

open access: yes, 1986
A later version of this paper was published as: Schafer, N.E. (1986). "Professionalism in the Alaska Department of Corrections: Education and Experience." The Justice Professional 1(2): 78–95 (Fall 1986).A survey of Alaska corrections personnel reveals ...
Schafer, N. E.
core  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

open access: yesFEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda   +12 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Prison Rehabilitation: The Sociological, Physiological, and Psychological Effects of Animal-Assisted Interventions [PDF]

open access: yes, 2018
This paper examines animal-assisted interventions as a new form of rehabilitation in the prison setting. It focuses specifically on the multiple benefits that this form of therapy/intervention can bring to inmates, such as the reduction in recidivism and
Corleto, Daisy
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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