Results 91 to 100 of about 194,399 (303)

Periodical Maintenance Modelling and Optimisation Assuming Imperfect Preventive Maintenance and Perfect Corrective Maintenance

, 2021
In this paper, a periodic maintenance model is formulated assumingcontinuous monitoring, imperfect preventive maintenance (PM) and perfect correctivemaintenance (CM) using three decision variables, (I, N, Z). The model is derived in aninfinite horizon context where the mean cost per unit time is modelled.
Engvall Birr, Madeleine, Lansryd, Lisette   +1 more
openaire   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Factors influencing restoration time in railways

Transportation Research Interdisciplinary Perspectives
Railway incidents undermine both punctuality and capacity. As traffic volumes increase, the frequency of these incidents is also expected to increase, driven by higher asset utilization, reduced time for maintenance, and further worsened by climate ...
Grace Mukunzi, Emil Jansson, Carl-William Palmqvist   +2 more
doaj   +1 more source

Usulan Strategi Perawatan Mesin Breaker dan Mesin Hammermill di PT. P&P Bangkinang

Jurnal Teknik Industri: Jurnal Hasil Penelitian dan Karya Ilmiah dalam Bidang Teknik Industri, 2017
PT. P & P Bangkinang merupakan sebuah  perusahaan yang bergerak dalam pengolahan karet PT. P & P Bangkinang merupakan sebuah  perusahaan yang bergerak dalam pengolahan karet mentah menjadi barang setengah jadi (Crumb Rubber) yang diekspor keluar negeri ...
wresni anggraini
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Tracking Report 2011 Hanesbrands, India 720232875GV [PDF]

, 2011
This document is part of a digital collection provided by the Martin P. Catherwood Library, ILR School, Cornell University, pertaining to the effects of globalization on the workplace worldwide.
Fair Labor Association
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Optimisation of railway tamping scheduling

Heliyon
This research was devoted to optimising opportunistic tamping scheduling to present a cost-effective approach that considers both preventive and corrective tamping activities.
Mahdi Khosravi, Alireza Ahmadi, Ahmad Kasraei, Arne Nissen   +3 more
doaj   +1 more source

The technical systems preventive maintenance trade-off model

Vojnotehnički Glasnik, 1996
A complex technical system preventive maintenance model based on a 'trade-off' between maximum availability and cost-effectiveness criterions was developed.
Svetomir Minić , Živan Arsenić , Jovan Todorović   +2 more
doaj   +1 more source