Results 101 to 110 of about 194,399 (303)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

A literature review-based evaluation framework for maintenance strategy selection in heavy vehicles

Results in Engineering
Effective maintenance strategies are critical for ensuring operational reliability, minimizing downtime, and optimizing resource utilization in fleet-based industrial operations.
Malihe Goli, Behzad Ghodrati, Nick Eleftheroglou   +2 more
doaj   +1 more source

Filling machine preventive maintenance using age replacement method in PT Lucas Djaja

MATEC Web of Conferences, 2018
PT Lucas Djaja is a company engaged in the pharmaceutical industry which produce sterile drugs and non-sterile. Filling machine has a high failure rate and expensive corrective maintenance cost.
Mustofa Fifi Herni, Utomo Ria Ferdian, Soemadi Kusmaningrum   +2 more
doaj   +1 more source

An Effective Predictive Maintenance Approach based on Historical Maintenance Data using a Probabilistic Risk Assessment: PHM14 Data Challenge

International Journal of Prognostics and Health Management, 2014
This paper presents an effective health assessment and predictive maintenance technique for industrial assets. The technique and algorithms applied to data sets provided by the Prognostics and Health Management Society 2014 Data Challenge.
Seyed Mohammad Rezvanizaniani, Jacob Dempsey, Jay Lee   +2 more
doaj   +1 more source

Maintenance optimization of high voltage substation model [PDF]

, 2008
The real system from practice is selected for optimization purpose in this paper. We describe the real scheme of a high voltage (HV) substation in different work states. Model scheme of the HV substation 22 kV is demonstrated within the paper.
Briš, Radim, Gala, Jan
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

DEVELOPMENT OF LOCOMOTIVE CC 203 MAINTENANCE STRATEGY USING RISK-BASED RELIABILITY CENTERED MAINTENANCE (RCM 3) METHOD

Rekayasa Mesin
Trains play a vital role in Indonesia's transportation system as they help reduce exhaust emissions and are one of the most environmentally friendly modes of transportation.
Oky Arfiansyah, I Gusti Nyoman Wiratmaja
doaj   +1 more source

Utilización de la metodología six sigma para el mejoramiento del proceso de servicios del taller de un concesionarío de vehículos, Guayaquil [PDF]

, 2009
The following research has been developed in the Maintenance and Repair department of a car dealer which sold from the start heavy and small cars, for that reason, a brief explanation of the process is made.
Ortiz, Rafael, Silva, Kleber, Vásquez, César   +2 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source