Results 121 to 130 of about 1,252,142 (297)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Management of the Industrial Maintenance at the International Level (I) [PDF]

When defining a maintenance policy, it must be held in mind the fact that there isn’t such a thing like “good maintenance policy” in itself; instead, for each industrial equipment should be adapted a particular maintenance method, coming to a technical ...
Florea PARVU, Gheorghe CARSTEA, Vasile DEAC, Florica BADEA, Constantin BAGU   +4 more
core  

A quantitative comparison of corrective and perfective maintenance [PDF]

, 1994
This paper presents a quantitative comparison of corrective and perfective software maintenance activities. The comparison utilizes basic data collected throughout the maintenance process.
Cain, James, Henry, Joel
core  

Reliability Assessment and Profit Optimization of Multi-Unit Mixed Configured System Using ABC Algorithm Under Preventive Maintenance

IEEE Access
This paper presents an arrangement of parallel and series concepts to determine the reliability features of a multifaceted system. The profit analysis examined the overall gain of the setup after maintenance, preventive maintenance, and corrective ...
Abdullah Ali H. Ahmadini, Shakuntla Singla, Diksha Mangla, Umar Muhammad Modibbo, Shilpa Rani   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Reliability Degradation, Preventive and Corrective Maintenance of UAV Systems

, 2018
In this paper we examine the problem of the preventive and corrective maintenance of UAVs systems taking into account the specific needs of the unmanned machine (and therefore completely different from the needs of a normal airplane) to define the ...
Lorenzo Ciani, Leccese, Fabio, Petritoli, Enrico, Ciani, Lorenzo, Enrico Petritoli, Fabio Leccese   +5 more
core   +1 more source

Optimization of maintenance planning in power distribution systems using a discrete-time Markov chain model asset analysis and resource allocation

Energy Strategy Reviews
This study aims to optimize maintenance planning in power distribution systems by addressing the complexity of operational states, resource allocation, and the high costs associated with preventive and corrective maintenance.
Mohammad Taghi Tahooneh, Aidin Shaghaghi, Vahid Rezaei, Rahim Zahedi, Reza Dashti   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Addressing the use of drugs in prison : prevalence, nature and context

, 2003
Corporate Research Evaluation & Statistics, NSW Dept.
Kevin, Maria, New South Wales. Dept. of Corrective Services   +1 more
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source