Results 61 to 70 of about 1,252,142 (297)

Transient outage model considering corrective and preventive maintenance

Journal of Modern Power Systems and Clean Energy, 2016
Traditional outage model for the power equipment usually focus on the behavior of the equipment under random factors, and the availability of the power equipment in system analysis is usually confined to the steady value.
Guoqiang Ji, Wenchuan Wu, Boming Zhang, Hongbin Sun   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Budget Forecasting for US Marine Corps Corrective Maintenance Costs [PDF]

, 2020
Panel #18: Cost and Pricing in the 21st CenturyAcquisition Research: Creating Synergy for Informed Change. 17th Annual Acquisition Research SymposiumThis project presents some methodologies to forecast corrective maintenance costs of the 1st Marine ...
Dahel, Eddine
core   +1 more source

The Management of the Industrial Maintenance at an International Level (II) [PDF]

Revista de Management Comparat International, 2011
When defining a maintenance policy, it must be held in mind the fact that there isn’t such a thing like “good maintenance policy” in itself; instead, for each industrial equipment should be adapted a particular maintenance method, coming to a ...
Vasile DEAC, Gheorghe CÂRSTEA , Gheorghe CÂRSTEA , Florea PÂRVU   +3 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Optimal maintenance policies under different operational schedules [PDF]

, 2005
In the reliability literature, maintenance time is usually ignored during the optimization of maintenance policies. In some scenarios, costs due to system failures may vary with time, and the ignorance of maintenance time will lead to unrealistic results.
Clements-Croome, Derek, Wu, Shaomin, Clements-Croome, D., Wu, S. M.   +3 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Time Dependent Perfect Corrective Maintenance Policy

, 2022
International audienceThe same maintenance actions could induce different costs during time. In this paper, a single-unit system is considered under the lifetime test.
Fouladirad, Mitra, Firoozeh, Haghighi, Misaii, Hasan   +2 more
core   +2 more sources