Results 41 to 50 of about 36,041 (312)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Driving simulator-based training to improve self-rating ability of driving performance in older adults – a pilot study

European Transport Research Review, 2019
Objective The aim was to investigate the potential of using simulator-based training (SBT) to improve older drivers' self-rating ability and to compare two forms of feedback; corrective versus corrective and rewarding feedback.
Helena Selander, Christina Stave, Tania Dukic WiIlstrand, Björn Peters   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Investigating the Effects of Sport-Metric Training on Functional Factors Related to Lower Limb Injuries and Skill Variables in Young Futsal Players [PDF]

Biyumikānīk-i varzishī
Objective The present study aimed to examine the effects of injury prevention training using the Sport-Metric method on functional factors associated with reducing the risk of lower extremity injuries, as well as skill-related variables in young futsal ...
Mohammad Kalantariyan, Sirvan Zarghami Aliabad, Jamal Khalandi   +2 more
doaj  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Correcting Auto-Differentiation in Neural-ODE Training

CoRR, 2023
Accepted for publication in SIAM Journal on Applied Mathematics.
Yewei Xu, Shi Chen 0003, Qin Li 0007, Stephen J. Wright 0001   +3 more
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Corrective Osteotomy for Bilateral Madelung’s Deformity

, 2014
Madelung’s deformity is the developmental anomaly of the wrist. Delayed growth rate of the medial side of the distal radius growth plate and articular surface rotation causing relatively shortening of the medial side of the radius are considered to be ...
GÖÇER, HASAN, Hasan Göçer, Alper Çıraklı, KUYUBAŞI, SABİT NUMAN, ÇIRAKLI, ALPER, Sabit Numan Kuyubaşı   +5 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Effects of repeated waist-pull perturbations on gait stability in subjects with cerebellar ataxia

Journal of NeuroEngineering and Rehabilitation, 2019
Background Damage to the cerebellum can affect neural structures involved in locomotion, causing gait and balance disorders. However, the integrity of cerebellum does not seem to be critical in managing sudden and unexpected environmental changes such as
Federica Aprigliano, Dario Martelli, Jiyeon Kang, Sheng-Han Kuo, Un J. Kang, Vito Monaco, Silvestro Micera, Sunil K. Agrawal   +7 more
doaj   +1 more source