Results 121 to 130 of about 6,729,386 (312)

On the Sampling Variance of Intraclass Correlations and Genetic Correlations [PDF]

open access: yesGenetics, 1998
Abstract Widely used standard expressions for the sampling variance of intraclass correlations and genetic correlation coefficients were reviewed for small and large sample sizes. For the sampling variance of the intraclass correlation, it was shown by simulation that the commonly used expression, derived using a first-order Taylor ...
openaire   +5 more sources

Measuring Financial Contagion by Local Gaussian Correlation [PDF]

open access: yes
This paper examines financial contagion, that is, whether the cross-market linkages in financial markets increases after a shock to a country. We introduce the use of a new measure of local dependence (introduced by Hufthammer and Tjøstheim (2009)) to ...
Hufthammer, Karl Ove   +2 more
core  

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Time-stratified prognostic factors for poor renal outcomes in childhood-onset lupus nephritis: a systematic review and meta-analysis

open access: yesFrontiers in Immunology
ObjectivesTo identify prognostic factors independently associated with poor renal outcomes in childhood-onset lupus nephritis (cLN) based on multivariable analyses.MethodsSeven databases were searched up until October 2025.
Yuanhui Hu   +39 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Editorial: Singular and Correlation Optics

open access: yesFrontiers in Physics, 2021
Oleg V. Angelsky   +6 more
doaj   +1 more source

M1 and M2 Macrophage Polarization Correlates with Activity and Chronicity Indices in Lupus Nephritis

open access: yesLife
Background: Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE), characterized by inflammation and immune dysregulation in the kidneys.
Chutima Chavanisakun   +2 more
doaj   +1 more source

Correlation Structure of International Equity Markets During Extremely Volatile Periods [PDF]

open access: yes
Correlation in international equity returns is unstable over time. It has been suggested that the international correlation of large stock returns, especially negative ones, differs from that of usual returns. It is in periods of extreme negative returns
Bruno, SOLNIK, François, LONGIN
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy