Results 71 to 80 of about 4,161,419 (298)

Human-Smart Environment Interactions in Smart Cities: Exploring Dimensionalities of Smartness

Future Internet, 2020
In the context of the challenges facing human computer interaction (HCI) on the one hand and the future Internet on the other, the purpose of this study is to explore the multi-dimensionality of smart cities, looking at relationships and ...
H. Patricia McKenna
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Mathematical Determination of the Cultural Interaction between Medieval Groups

Journal of Mathematical Sciences and Modelling, 2020
A mathematical classification of two-dimensional ornaments into 17 plane symmetry groups is presented, which were created by five medieval cultural groups of Middle East. The data are considered representative for the cultural groups.
Mehmet Erbudak
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Challenges and support needs among persons with a migration background who use drugs in four European metropolitan cities

Harm Reduction Journal
Background Persons who migrate for economic reasons, along with asylum seekers and refugees, face multiple personal experiences and societal inequalities that increase the risk of mental health problems and substance dependency, compounded by ...
Aline Pouille, Clara De Ruysscher, Lena van Selm, Jan van Amsterdam, Wim van den Brink, Machteld Busz, Roberto Perez Gayo, Marios Atzemis, Wouter Vanderplasschen, the SEMID-EU consortium   +9 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Editorial: Low-dimensional structures, nanoparticles, and optical measurements

Frontiers in Physics, 2022
Claudia Yu. Zenkova, Claudia Yu. Zenkova, Oleg V. Angelsky, Oleg V. Angelsky, Steen G. Hanson, Igor I. Mokhun   +5 more
doaj   +1 more source

Advances on cancer vaccine trials registered in China and the USA in 2014-2024

Frontiers in Oncology
ObjectiveThe clinical trials of cancer vaccine in China and the USA were summarized and compared over the past decade, thus putting forward suggestions for future clinical development in this field.MethodsMainly based on the Centre for Drug Evaluation of
Wei Shi, Wei Shi, Wei Shi, Wei Shi, Zhuo Chen, Zhuo Chen, Zhuo Chen, Zhuo Chen, Qin Yu, Qin Yu, Qin Yu, Qin Yu, Lingli Zhang, Lingli Zhang, Lingli Zhang, Lingli Zhang, Lingli Zhang, Lingli Zhang   +17 more
doaj   +1 more source