Results 121 to 130 of about 196,680 (343)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
CpGFilter: CpG Filtering Method Based on Intra-Class Correlation Coefficients [PDF]
, 2014 Jun Chen
openalex +1 more source
Research on Calibration Method of Electronic Transformer Based on Correlation and Lattice Notch Filter [PDF]
, 2022 Mianzhou Chen, Hongbin Li, Chuanji Zhang
openalex +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Design of UWB pulse radio transceiver using statistical correlation technique in frequency domain [PDF]
Advances in Radio Science, 2007 In this paper, we propose a new technique to extract low power UWB pulse radio signals, near to noise level, using statistical correlation technique in frequency domain.
M. Anis, R. Tielert
doaj
Correlation between large- and small-scale velocity components under Fourier filters
Theoretical and Applied Mechanics Letters, 2014 By introducing the Fourier filters, we analyse the correlation between large- and small-scale velocity components in homogeneous isotropic turbulence theoretically. We show that different Fourier filters act similarly on this multi-scale correlation with
Le Fang
doaj +1 more source
Correlation and Convolution Image Filtering Application Analysis [PDF]
, 2017 Xihu Zhi, Shengli Jiang
openalex +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Adaptive Spatial Regularization Correlation Filters for UAV Tracking
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingAs a tool for near-earth remote sensing, unmanned aerial vehicle (UAV) can be used to acquire images and data of the earth's surface. This provides a powerful support for Earth observation and resource management. Object tracking in UAV videos has
Yulin Cao +5 more
doaj +1 more source