Results 51 to 60 of about 1,307 (196)

On the Internet Everybody Knows You’re a Whatchamacallit (or a Thing) [PDF]

open access: yes, 2017
The Internet of Things (IoT) is fed by, and feeds into, flowing data streams. Through these flows, servers, sensors, humans and alike are networked together, data and networks mediating between physical and digital realms.
Coulton, Paul, Lindley, Joseph Galen
core  

Meillassoux, Correlationism, and the Ontological Difference

open access: yesPhaenEx, 2018
Meillassoux defines “correlationism” as the view that we can only access the mutual dependence of thought and being—specifically, subjectivity and objectivity—which he attributes to Heidegger. This attribution is inapt. It is only by accessing being—via existential analysis—that we can properly distinguish beings like subjects and objects.
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

On the Difference Between Being and Object [PDF]

open access: yes, 2019
If philosophy in the wake of Kant’s transcendental revolution tends to orient itself around a subjective principle, namely the human subject, then recently various schools of thought have proposed a counter-revolution in which philosophy is given an ...
Osborn, James
core   +1 more source

Hume's Correlationism: On Meillassoux, Necessity and Belief

open access: yesJournal of French and Francophone Philosophy, 2013
The article argues that Meillassoux's 'After Finitude' underestimates the nature and profundity of Hume's sceptical challenge; it neglects the fact that Hume's scepticism concerns final causes (and agrees fundamentally with Bacon and Descartes in this respect), and that in Hume even the operations of reason do not furnish entirely a priori knowledge ...
openaire   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Rewriting the Constitution::A Critique of 'Postphenomenology'' [PDF]

open access: yes, 2015
This paper builds a three part argument in favour of a more transcendentally focused form of 'postphenomenology' than is currently practised in philosophy of technology.
A Badiou   +32 more
core   +2 more sources

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