Results 51 to 60 of about 493 (179)
AM: Art + Media, 2016 This paper deals with the transformations of Šalamun’s oeuvre in relation to the developments of philosophical platforms which he had been exposed to in the course of his creative life.
Vladimir Đurišić
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Meillassoux, correlationism, and phenomenological transcript analysis
Meillassoux’s description and critique of correlationism, and Zahavi’s response to Meillassoux are here recruited to explore underinvestigated aspects of qualitative research.
Lipscomb, Martin
core +3 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Deriving the Spiritual from the Material: A Speculatively Realist Perspective
ReligionsThe existence of the spiritual can be deduced from knowledge of the material. There is an inherent affinity between speculation and spirituality: an embrace of gaps in knowledge.
Ian McLaughlin
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 2016 The aim of this paper is threefold. First, we examine the Sellarsian concept of the (myth of the) categorial Given, focus on its wide application and suggest that it can be applied to those post-Kantian philosophical views, currently fashionable in ...
Christias, D.
core +1 more source
Cognition as Communication: Exploring Niklas Luhmann's Theory of Knowledge
Principia: An International Journal of EpistemologyThis article delves into the epistemology inherent in Niklas Luhmann's theory of social systems, specifically focusing on the concept of cognition.
Jesper Tække
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source