Results 231 to 240 of about 2,266,709 (311)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Reliability and Validity of the Japanese Version of the Inventory of Psychotic-Like Anomalous Self-Experiences. [PDF]

Int J Methods Psychiatr Res
Nakamura D, Mizuno M, Cicero D, Arai Y, Suzuki H, Hirose S, Kasai T, Sugita S, Nakamura Y, Wood S, Polari A, Nemoto T, Nelson B.   +12 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Using eye tracking to explore the relationship between autism traits, joint attention, cognition and adaptive functioning in preschool children. [PDF]

J Neurodev Disord
Stylianakis AA, Pincham H, Chawla S, Mathew NE, Eapen V.   +4 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Real-world experience: correlation of three dyspnoea questionnaires with measures of disease severity and progression in patients with interstitial lung diseases. [PDF]

BMJ Open Respir Res
Moran-MacDonald A, Alyami S, Aldhaheri S, Kish M, Davison S, Moran-Mendoza O.   +5 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The Turkish Version of the Modified Agitation Severity Scale: Validity and Reliability Study. [PDF]

Int J Methods Psychiatr Res
Oflaz F, Çetinay Aydın P, Şahin Tokatlıoğlu T, Yıldırım YE, Demirel KF, Efe E.   +5 more
europepmc   +1 more source