Results 221 to 230 of about 2,266,709 (311)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Genetic association of productive traits, carcass measurements and age at first calving in the genetic evaluation of the Nellore breed. [PDF]

Trop Anim Health Prod
Menezes FL, Araújo SI, Lobo RB, Nakabashi LRM, Baldi F, Pavan NL, Seidel GCI, Araújo CV.   +7 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Separating extracellular from intracellular fecal metabolites exposes cross-feeding architecture in the gut: exploring metabolite partitioning and ecological associations. [PDF]

Gut Microbes
Hirayama M, Takame F, Maeda T, Kashihara K, Ito M, Ohno K, Ueyama J.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Compartment-specific inflammation in tuberculous lymphadenitis: a case-control study. [PDF]

Inflamm Res
Vinhaes CL, da Silveira SA, Barreto-Duarte B, Andrade BB, Sant'Anna FM, Schmaltz CAS, Ridolfi FM, Rolla VC, Gomes-Silva A, Extrapulmonary Tuberculosis Group.   +9 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Human gut microbiome as a composite health biomarker. [PDF]

Gut Microbes
Braun T, Harounian O, Hadar R, Ziv A, Ben-Avraham Shulman S, Kalter-Leibovici O, Efroni G, Ziv R, Fenesh M, Abbas-Egbariya H, Abramovich I, Amit S, Keller N, Truman K, Segev S, Amir A, Haberman Y.   +16 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

High-Pressure Density Measurements and Modeling of Hydrocarbons: 1-Hexene, 2, 4-Dimethylhexane, 2,2,4-Trimethylpentane, and <i>n</i>-Heptane. [PDF]

Int J Thermophys
Alt D, Hopp B, Staubach J, Hasse H, Stephan S.   +4 more
europepmc   +1 more source