Results 141 to 150 of about 5,341,246 (306)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Gard, Sven -- 1947-66 -- Correspondence, Individual -- letter, 1950-12-01

open access: yes, 1950
Letter from Sabin, Albert B. (Albert Bruce), 1906-1993 -- Correspondence to Goldforb, A. J.
Sabin, Albert B. (Albert Bruce), 1906-1993 -- Correspondence
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

ACTU correspondence, 1979 (5) [Folder Title]

open access: yes
This folder contains correspondence sent to the Australian Council of Trade Unions (ACTU) from various individuals and community organisations seeking assistance, asking for advice, responding to media reports and offering support.

core  

Ginder, David -- 1947-65 -- Correspondence, Individual -- letter, 1949-07-22

open access: yes, 1949
Letter from Sabin, Albert B. (Albert Bruce), 1906-1993 -- Correspondence to Wilson, Frank dated 1949-07-22.Sabin Collection Fair Use ...
Sabin, Albert B. (Albert Bruce), 1906-1993 -- Correspondence
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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