Soil microbial community response to corrinoids is shaped by a natural reservoir of vitamin B12. [PDF]
ISME JSoil microbial communities perform critical ecosystem services through the collective metabolic activities of numerous individual organisms. Most microbes use corrinoids, a structurally diverse family of cofactors related to vitamin B12.
Hallberg ZF +9 more
europepmc +7 more sources
Genetic dissection of regulation by a repressing and novel activating corrinoid riboswitch enables engineering of synthetic riboswitches [PDF]
mBio, 2023 The ability to sense and respond to intracellular metabolite levels enables cells to adapt to environmental conditions. Many prokaryotes use riboswitches—structured RNA elements usually located in the 5′ untranslated region of mRNAs—to sense ...
Rebecca R. Procknow +4 more
doaj +4 more sources
Genetic Analysis of Citrobacter sp.86 Reveals Involvement of Corrinoids in Chlordecone and Lindane Biotransformations [PDF]
Frontiers in Microbiology, 2020 Chlordecone (Kepone®) and γ-hexachlorocyclohexane (γ-HCH or lindane) have been used for decades in the French West Indies (FWI) resulting in long-term soil and water pollution. In a previous work, we have identified a new Citrobacter species (sp.86) that
Agnès Barbance +11 more
doaj +3 more sources
Mercury Methylation by Cobalt Corrinoids: Relativistic Effects Dictate the Reaction Mechanism [PDF]
Angewandte Chemie, 2016 The methylation of Hg(II) (SCH3 )2 by corrinoid-based methyl donors proceeds in a concerted manner through a single transition state by transfer of a methyl radical, in contrast to previously proposed reaction mechanisms.
Taye B. Demissie +3 more
semanticscholar +3 more sources
Resonance Raman Optical Activity Spectroscopy in Probing Structural Changes Invisible to Circular Dichroism Spectroscopy: A Study on Truncated Vitamin B12 Derivatives [PDF]
Molecules, 2020 This work demonstrates resonance Raman optical activity (RROA) spectra of three truncated vitamin B12 derivatives modified within the nucleotide loop. Since truncated cobalamins possess sufficiently high rotational strength in the range of ROA excitation
Ewa Machalska +5 more
doaj +5 more sources
Cobalamin Riboswitches Are Broadly Sensitive to Corrinoid Cofactors to Enable an Efficient Gene Regulatory Strategy [PDF]
mBio, 2022 In bacteria, many essential metabolic processes are controlled by riboswitches, gene regulatory RNAs that directly bind and detect metabolites. Highly specific effector binding enables riboswitches to respond to a single biologically relevant metabolite.
Kristopher J. Kennedy +6 more
doaj +2 more sources
Identification of specific corrinoids reveals corrinoid modification in dechlorinating microbial communities. [PDF]
Environmental Microbiology, 2015 Cobalamin and other corrinoids are essential cofactors for many organisms. The majority of microbes with corrinoid-dependent enzymes do not produce corrinoids de novo, and instead must acquire corrinoids produced by other organisms in their environment ...
Y. Men +6 more
semanticscholar +5 more sources
Mouse transcobalamin has features resembling both human transcobalamin and haptocorrin. [PDF]
PLoS ONE, 2011 In humans, the cobalamin (Cbl) -binding protein transcobalamin (TC) transports Cbl from the intestine and into all the cells of the body, whereas the glycoprotein haptocorrin (HC), which is present in both blood and exocrine secretions, is able to bind ...
Katrine Hygum +7 more
doaj +13 more sources
Protein binding assays for an accurate differentiation of vitamin B12 from its inactive analogue. A study on edible cricket powder [PDF]
Food Chemistry: X, 2023 Inactive analogues of vitamin B12 (cobalamin, Cbl) can mimic the active Cbl in food if using the traditional microbiological measurements. Thus, overestimated Cbl was recently revealed in edible insects employing immunoaffinity adsorption, HPLC ...
Sergey N. Fedosov +4 more
doaj +2 more sources
Nutrient sharing in the microbial world [PDF]
Frontiers in Microbiology, 2014 The stability and function of a microbial community depends on nutritional interactions among community members such as the cross-feeding of essential small molecules synthesized by a subset of the population.
Erica Christine Seth, Michiko E Taga
doaj +4 more sources