Cobalamin Riboswitches Are Broadly Sensitive to Corrinoid Cofactors to Enable an Efficient Gene Regulatory Strategy [PDF]
mBio, 2022 In bacteria, many essential metabolic processes are controlled by riboswitches, gene regulatory RNAs that directly bind and detect metabolites. Highly specific effector binding enables riboswitches to respond to a single biologically relevant metabolite.
Kristopher J. Kennedy +6 more
doaj +4 more sources
Genetic Analysis of Citrobacter sp.86 Reveals Involvement of Corrinoids in Chlordecone and Lindane Biotransformations [PDF]
Frontiers in Microbiology, 2020 Chlordecone (Kepone®) and γ-hexachlorocyclohexane (γ-HCH or lindane) have been used for decades in the French West Indies (FWI) resulting in long-term soil and water pollution. In a previous work, we have identified a new Citrobacter species (sp.86) that
Agnès Barbance +11 more
doaj +4 more sources
Genetic dissection of regulation by a repressing and novel activating corrinoid riboswitch enables engineering of synthetic riboswitches [PDF]
mBio, 2023 The ability to sense and respond to intracellular metabolite levels enables cells to adapt to environmental conditions. Many prokaryotes use riboswitches—structured RNA elements usually located in the 5′ untranslated region of mRNAs—to sense ...
Rebecca R. Procknow +4 more
doaj +4 more sources
Soil microbial community response to corrinoids is shaped by a natural reservoir of vitamin B12. [PDF]
ISME JSoil microbial communities perform critical ecosystem services through the collective metabolic activities of numerous individual organisms. Most microbes use corrinoids, a structurally diverse family of cofactors related to vitamin B12.
Hallberg ZF +9 more
europepmc +6 more sources
Novel Pathway for Corrinoid Compounds Production in Lactobacillus [PDF]
Frontiers in Microbiology, 2018 Vitamin B12 or cobalamin is an essential metabolite for humans, which makes it an interesting compound for many research groups that focus in different producer-strains synthesis pathways.
Andrea Carolina Torres +4 more
core +9 more sources
Protein binding assays for an accurate differentiation of vitamin B12 from its inactive analogue. A study on edible cricket powder [PDF]
Food Chemistry: X, 2023 Inactive analogues of vitamin B12 (cobalamin, Cbl) can mimic the active Cbl in food if using the traditional microbiological measurements. Thus, overestimated Cbl was recently revealed in edible insects employing immunoaffinity adsorption, HPLC ...
Sergey N. Fedosov +4 more
doaj +2 more sources
Nutrient sharing in the microbial world [PDF]
Frontiers in Microbiology, 2014 The stability and function of a microbial community depends on nutritional interactions among community members such as the cross-feeding of essential small molecules synthesized by a subset of the population.
Erica Christine Seth, Michiko E Taga
doaj +4 more sources
Human gut Bacteroides capture vitamin B12 via cell surface-exposed lipoproteins [PDF]
eLife, 2018 Human gut Bacteroides use surface-exposed lipoproteins to bind and metabolize complex polysaccharides. Although vitamins and other nutrients are also essential for commensal fitness, much less is known about how commensal bacteria compete with each other
Aaron G Wexler +5 more
doaj +3 more sources
Cobamide metabolism, regulation, and adaptation in Mycobacterium tuberculosis [PDF]
Journal of BacteriologyCobamides play a paradoxical but critical role in the biology of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis. Although Mtb retains nearly all cobalamin (Cbl) biosynthetic genes and encodes multiple cobamide-requiring enzymes ...
Terry Kipkorir +4 more
doaj +2 more sources
Identification of a Novel Cobamide Remodeling Enzyme in the Beneficial Human Gut Bacterium
mBio, 2020 The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A.
Kenny C. Mok +6 more
doaj +2 more sources