Results 11 to 20 of about 1,224 (179)

Identification of specific corrinoids reveals corrinoid modification in dechlorinating microbial communities [PDF]

Environmental Microbiology, 2014
Summary Cobalamin and other corrinoids are essential cofactors for many organisms. The majority of microbes with corrinoid‐dependent enzymes do not produce corrinoids de novo , and instead must acquire corrinoids produced by other organisms in their environment. However, the
Men, Yujie, Seth, Erica C, Yi, Shan, Crofts, Terence S, Allen, Robert H, Taga, Michiko E, Alvarez-Cohen, Lisa   +6 more
openaire   +6 more sources

Soil microbial community response to corrinoids is shaped by a natural reservoir of vitamin B12. [PDF]

ISME J
Soil microbial communities perform critical ecosystem services through the collective metabolic activities of numerous individual organisms. Most microbes use corrinoids, a structurally diverse family of cofactors related to vitamin B12.
Hallberg ZF, Nicolas AM, Alvarez-Aponte ZI, Mok KC, Sieradzki ET, Pett-Ridge J, Banfield JF, Carlson HK, Firestone MK, Taga ME.   +9 more
europepmc   +2 more sources

NMR-restrained molecular modeling of cobalt corrinoids: cyanocobalamin (vitamin B12) and methylcobalt corrinoids

Journal of Molecular Structure: THEOCHEM, 1998
Abstract NMR-restrained molecular dynamics (MD) and simulated annealing (SA) calculations have been performed on cyanocobalamin (CNCbl, vitamin B 12 ), and three methylcobalt corrinoids, the coenzymatically active methylcobalamin (CH 3 Cbl), and two analogs of its base-off species, methylcobinamide (CH 3 Cbi + ), which lacks an axial nucleotide, and ...
Kenneth L Brown, Xiang Zou, Helder M Marques   +2 more
openaire   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B₁₂-binding function. [PDF]

FEBS Open Bio
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Clarke C, Banasik M, Juodeikis R, Warren MJ, Pickersgill RW.   +4 more
europepmc   +2 more sources

Biological activities of new corrinoids.

Agricultural and Biological Chemistry, 1982
KAMIKUBO, Tadashi, MATSUNO, Ryuichi, BIEGANOWSKI, Ranier, SENKPIEL, Birgit, FRIEDRICH, Wilhelm   +4 more
core   +4 more sources

Evidence for corrin biosynthesis in the last universal common ancestor. [PDF]

FEBS J
Cobalamin biosynthesis can be traced back to the last universal common ancestor. After a stage of chemical evolution of the acetyl‐CoA pathway, the enzymatic synthesis of cobalamin evolved, allowing life to be independent of the insoluble solid‐state catalysts that tethered primordial CO2 assimilation to the Earth's crust, suggesting a role for corrin ...
Modjewski LD, Karavaeva V, Mrnjavac N, Knopp M, Martin WF, Sousa FL.   +5 more
europepmc   +2 more sources

Mobilization of vitamin B₁₂ transporters alters competitive dynamics in a human gut microbe. [PDF]

Cell Rep, 2021
The functional and genomic diversity of the human gut microbiome is shaped by horizontal transfer of mobile genetic elements (MGEs). Characterized MGEs can encode genes beneficial for their host's self-defense (e.g., antibiotic resistance) or ability to ...
Frye KA, Piamthai V, Hsiao A, Degnan PH.
europepmc   +2 more sources

Genome-Based Metabolic Reconstruction Unravels the Key Role of B12 in Methionine Auxotrophy of an Ortho-Phenylphenol-Degrading Sphingomonas haloaromaticamans

Frontiers in Microbiology, 2020
Auxotrophy to amino acids and vitamins is a common feature in the bacterial world shaping microbial communities through cross-feeding relations. The amino acid auxotrophy of pollutant-degrading bacteria could hamper their bioremediation potential ...
Chiara Perruchon, Sotirios Vasileiadis, Evangelia S. Papadopoulou, Dimitrios G. Karpouzas   +3 more
doaj   +1 more source

Resonance Raman Optical Activity Spectroscopy in Probing Structural Changes Invisible to Circular Dichroism Spectroscopy: A Study on Truncated Vitamin B₁₂ Derivatives

Molecules, 2020
This work demonstrates resonance Raman optical activity (RROA) spectra of three truncated vitamin B12 derivatives modified within the nucleotide loop. Since truncated cobalamins possess sufficiently high rotational strength in the range of ROA excitation
Ewa Machalska, Grzegorz Zajac, Monika Halat, Aleksandra J. Wierzba, Dorota Gryko, Malgorzata Baranska   +5 more
doaj   +1 more source

Uncovering how bacteria sense and respond to chemically diverse corrinoids through cobalamin riboswitch gene regulation [PDF]

, 2021
Cells actively sense and integrate information about their internal and external environments to execute adaptive physiological responses. This makes it possible to survive fluctuating and oftentimes harsh environmental conditions.
Kennedy, Kristopher John
core   +1 more source