Genetic Analysis of Citrobacter sp.86 Reveals Involvement of Corrinoids in Chlordecone and Lindane Biotransformations [PDF]
Frontiers in Microbiology, 2020 Chlordecone (Kepone®) and γ-hexachlorocyclohexane (γ-HCH or lindane) have been used for decades in the French West Indies (FWI) resulting in long-term soil and water pollution. In a previous work, we have identified a new Citrobacter species (sp.86) that
Agnès Barbance +11 more
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Cobalamin Riboswitches Are Broadly Sensitive to Corrinoid Cofactors to Enable an Efficient Gene Regulatory Strategy [PDF]
mBio, 2022 In bacteria, many essential metabolic processes are controlled by riboswitches, gene regulatory RNAs that directly bind and detect metabolites. Highly specific effector binding enables riboswitches to respond to a single biologically relevant metabolite.
Kristopher J. Kennedy +6 more
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Genetic dissection of regulation by a repressing and novel activating corrinoid riboswitch enables engineering of synthetic riboswitches [PDF]
mBio, 2023 The ability to sense and respond to intracellular metabolite levels enables cells to adapt to environmental conditions. Many prokaryotes use riboswitches—structured RNA elements usually located in the 5′ untranslated region of mRNAs—to sense ...
Rebecca R. Procknow +4 more
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Protein binding assays for an accurate differentiation of vitamin B12 from its inactive analogue. A study on edible cricket powder [PDF]
Food Chemistry: X, 2023 Inactive analogues of vitamin B12 (cobalamin, Cbl) can mimic the active Cbl in food if using the traditional microbiological measurements. Thus, overestimated Cbl was recently revealed in edible insects employing immunoaffinity adsorption, HPLC ...
Sergey N. Fedosov +4 more
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Cobamide metabolism, regulation, and adaptation in Mycobacterium tuberculosis [PDF]
Journal of BacteriologyCobamides play a paradoxical but critical role in the biology of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis. Although Mtb retains nearly all cobalamin (Cbl) biosynthetic genes and encodes multiple cobamide-requiring enzymes ...
Terry Kipkorir +4 more
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Identification of a Novel Cobamide Remodeling Enzyme in the Beneficial Human Gut Bacterium
mBio, 2020 The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A.
Kenny C. Mok +6 more
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The prospects for the use of vitamin B12 derivatives in pharmacology
Фармакоэкономика, 2023 Background. The structure of corrin tetrapyrrole macrocycles (compounds similar in structure to vitamin B12) is a kind of universal chemical template for targeted drug delivery, and the development of chemical sensors and antidotes.Objective ...
I. Yu. Torshin +2 more
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A vitamin B12 transporter in Mycobacterium tuberculosis [PDF]
Open Biology, 2013 Vitamin B12-dependent enzymes function in core biochemical pathways in Mycobacterium tuberculosis, an obligate pathogen whose metabolism in vivo is poorly understood. Although M.
Krishnamoorthy Gopinath +6 more
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Characterization of Vitamin B12 Compounds in Fermented Poultry Manure Fertilizers
Agriculture, 2021 (1) Background: Currently, no data are available on the vitamin B12 content of an organic fertilizer product, viz. fermented poultry manure, or whether the organic fertilizer product contains vitamin B12 or inactive corrinoids (or both).
Hiromi Katsura +4 more
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Synergism of components as the main approach to creation of a probiotic complex
Медицинский совет, 2020 Development of probiotic products containing several strains: Bifidumbacterium lactis BI-04, Lactobacillus acidophilus La-14 and Lactobacillus rhamnosus Lr-32, is an upcoming trend, as it builds capacity of preventive treatment.
E. V. Shikh +2 more
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