Results 141 to 150 of about 48,170 (206)

Dexmedetomidine Rapidly Relieves Stress‐Induced Hyperalgesia via Presynaptic α2‐Adrenergic Inhibition at Orbitofrontal–Insular Glutamatergic Synapses

MedComm, Volume 7, Issue 7, July 2026.
This study identified a maladaptive OFC–AIC glutamatergic circuit in stress‐induced hyperalgesia induction. This critical circuit provides an α2‐AR‐dependent braking target for dexmedetomidine to alleviate excessive glutamatergic transmission and hyperalgesia. ABSTRACT Dexmedetomidine (Dex), an α2‐adrenergic receptor (α2‐AR) agonist, is widely used for
Hui Rong, Yang‐Xun Zhang, Huijie Zhu, Yinyao Li, Yunfan Hou, Yun‐Yong Xie, Lu‐Yao Li, Bei‐Bei Zhang, Shu‐Tao Xie, Wei Zhang, Qi‐Peng Zhang, Xiao‐Yang Zhang, Jing‐Ning Zhu, Xiaoping Gu, Zhengliang Ma   +14 more
wiley   +1 more source

Cortical motor activity modulates respiration and reduces apnoea in neonates. [PDF]

Elife
Zandvoort CS, Usman F, Robinson S, Fatunla O, Adams E, Pattinson KTS, Farmer SF, Hartley C.   +7 more
europepmc   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Modeling of Fiber Orientation‐Dependent R1 Relaxation in Human White Matter In Vivo Within The Framework of The Transient Hydrogen Bond Model

Magnetic Resonance in Medicine, Volume 96, Issue 1, Page 315-322, July 2026.
ABSTRACT Purpose Axon fiber orientation‐dependent R1 relaxation in human white matter (WM) in vivo at B0 = 1.5 T, 3 T, and 7 T was studied within the framework of the transient hydrogen bond (THB) model, which attributes MR signal relaxation to quantum magnetization interactions of water and motion‐restricted protons in hydrophilic heads of lipid ...
Dmitriy A. Yablonskiy, Risto A. Kauppinen, Ekaterina Paasonen, Jeromy Thotland, Mervi Könönen, Pramod Pisharady, Christophe Lenglet, Juhana M. Hakumäki, Olli H. J. Gröhn, Michael Garwood, Alexander L. Sukstanskii   +10 more
wiley   +1 more source

Abnormal Brain Structural Covariance Networks of Cortical Thickness in Cocaine Use Disorder

Addiction Biology, Volume 31, Issue 7, July 2026.
Cocaine use disorder (CUD) disrupts large‐scale brain network coordination. Using structural covariance network analysis, we found reduced local clustering, impaired rich‐club connectivity, and a shift toward lattice‐like organization in CUD patients, while global network robustness remained preserved. These findings reveal a dissociation between local
Linkai Chen, Youling Li, Jie Chen, Junshen Zhang, Xinyu Ma, Qiuling Cai, Guanghui Bai, Meimei Du   +7 more
wiley   +1 more source

Leituras de O cortiço (notas para um público estrangeiro)

Revista Brasileira de Literatura Comparada
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Paulo Franchetti
doaj  

A história da riqueza na literatura realista brasileira: O Cortiço em foco

, 2014
MACIEL, Siônio Gomes. A história da riqueza na literatura realista brasileira: O Cortiço em foco. 2014. 36f. Trabalho de Conclusão de Curso (Especialização em Fundamentos da Educação: Práticas Pedagógicas Interdisciplinares EAD) – Universidade Estadual ...
Maciel, Siônio Gomes
core  

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, Volume 183, Issue 14, Page 3992-4005, July 2026.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

Proline-Rich Transmembrane Protein 2 Is Variably Expressed Across Excitatory and Inhibitory Neurons in Mouse Motor Circuits. [PDF]

J Comp Neurol
Hatta D, Watanabe K, Kinoshita A, Yoshiura KI, Kurotaki N, Shirotani K, Iwata N.   +6 more
europepmc   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, Volume 183, Issue 14, Page 3897-3919, July 2026.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source