Results 41 to 50 of about 122,577 (292)

Cognitive Plasticity and Cortical Modules [PDF]

Current Directions in Psychological Science, 2009
Some organisms learn to calculate, accumulate knowledge, and communicate in ways that others do not. What factors determine which intellectual abilities a particular species or individual can easily acquire? I propose that cognitive-skill learning capacity reflects (a) the availability of specialized cortical circuits, (b) the flexibility with which ...
openaire   +2 more sources

Group I metabotropic glutamate receptors differentially modulate excitatory transmission across interneuron types in the human cortex

Frontiers in Synaptic Neuroscience
IntroductionGroup I metabotropic glutamate receptors (mGluRs) play a critical role in regulating neuronal excitability, synaptic strength, and cortical network activity. Although their physiological functions and involvement in neurological disorders are
Joanna Grace Sandle, Joanna Grace Sandle, Gábor Molnár, Martin Tóth, Katalin Ágnes Kocsis, Éva Adrienn Csajbók, Pál Barzó, Karri Lamsa, Karri Lamsa, Gábor Tamás   +9 more
doaj   +1 more source

Changes in Cortical Plasticity Across the Lifespan [PDF]

Frontiers in Aging Neuroscience, 2011
Deterioration of motor and cognitive performance with advancing age is well documented, but its cause remains unknown. Animal studies dating back to the late 1970s reveal that age-associated neurocognitive changes are linked to age-dependent changes in synaptic plasticity, including alterations of long-term potentiation and depression (LTP and LTD ...
Freitas, Catarina, Perez, Jennifer, Knobel, Mark, Tormos, Jose, Oberman, Lindsay, Eldaief, Mark, Bashir, Shahid, Vernet, Marine, Peña-Gómez, Cleofé, Pascual-Leone, Alvaro   +9 more
openaire   +5 more sources

Impaired motor cortical plasticity associated with cannabis use disorder in young adults

, 2020
Maladaptive cortical plasticity has been described in individuals with heroin and methamphetamine addiction and may mediate other substance abuse disorders. It is unknown whether cannabis dependence in humans alters the capacity for induction of cortical
Aizpurúa Olaizola, Oier, Rodríguez Baena, Antonio, Mir Rivera, Pablo, Canal Rivero, Manuel, Ruiz Veguilla, Miguel, Álvarez de Toledo, Paloma, Zarandona, Iratxe, Martín Rodríguez, Juan Francisco   +7 more
core   +1 more source

Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons

Cell Reports, 2019
Summary: Cortical hyperexcitability is a hallmark of fragile X syndrome (FXS). In the Fmr1 knockout (KO) mouse model of FXS, cortical hyperexcitability is linked to sensory hypersensitivity and seizure susceptibility.
Pernille Bülow, T.J. Murphy, Gary J. Bassell, Peter Wenner   +3 more
doaj   +1 more source

Visual Cortical Plasticity in Retinitis Pigmentosa [PDF]

Investigative Opthalmology & Visual Science, 2019
Retinitis pigmentosa is a family of genetic diseases inducing progressive photoreceptor degeneration. There is no cure for retinitis pigmentosa, but prospective therapeutic strategies are aimed at restoring or substituting retinal input. Yet, it is unclear whether the visual cortex of retinitis pigmentosa patients retains plasticity to react to the ...
Lunghi C., Galli-Resta L., Binda P., Cicchini G. M., Placidi G., Falsini B., Morrone M. C.   +6 more
openaire   +3 more sources

Dopaminergic Modulation of Cortical Plasticity in Alzheimer's Disease Patients

, 2014
In animal models of Alzheimer's disease (AD), mechanisms of cortical plasticity such as long-term potentiation (LTP) and long-term depression (LTD) are impaired. In AD patients, LTP-like cortical plasticity is abolished, whereas LTD seems to be preserved.
Di Lorenzo, Francesco, Bozzali, M, Martorana, A, Martorana, Alessandro, Marco Bozzali, Sonia Bonnì, Koch, G, Alessandro Martorana, Caltagirone, Carlo, Giacomo Koch, Bozzali, Marco, Bonnì, S, Francesco Di Lorenzo, Di Lorenzo, F, Caltagirone, C, Koch, Giacomo, Giacobbe, Viola, Giacobbe, V, Viola Giacobbe, Bonnì, Sonia, Carlo Caltagirone   +20 more
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Imprinting and cortical plasticity: A comparative review: a comparative review

, 1983
Bischof H-J. Imprinting and cortical plasticity: A comparative review: a comparative review. Neuroscience and Biobehavioral Reviews. 1983;7(2):213-225.Results of research on imprinting and developmental neurobiology of the visual cortex are compared to ...
Bischof, Hans-Joachim
core   +2 more sources

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source