Results 121 to 130 of about 53,540 (338)
Abstract Objectives Acute cerebral ischemia is characterized by several pathological processes evolving during time, which contribute to the final tissue damage. Secondary processes, such as prolonged inflammatory response, impaired mitochondrial function and oxidative stress, are responsible for the progression of brain injury to the peri‐infarct area,
Fioravante Capone+8 more
wiley +1 more source
Spinal and cortical spreading depression enhance spinal cord activity
Cortical spreading depression (CSD) has been suggested to underlie some neurological disorders such as migraine. Despite the intensity with which many investigators have studied SD in the brain, only a few studies have aimed to identify SD in the spinal ...
A Gorji+3 more
doaj
Progress of non‐motor symptoms in early‐onset Parkinson's disease
This study reviews the research progress related to non‐motor symptoms (NMS) in patients with early onset Parkinson's disease (EOPD), including neuropsychiatric symptoms, autonomic dysfunction, sleep disorders, and sensory disorders and also summarizes the characteristics of NMS in the genetic form of Parkinson's disease (PD).
Fanshi Zhang+5 more
wiley +1 more source
Abstract Background Posttraumatic stress disorder (PTSD) is associated with autonomic dysfunction as indicated by deficits in the sympathetic and parasympathetic nervous systems. These abnormalities are expressed as elevated heart rate and reduced heart rate variability (HRV), respectively.
Camila Cosmo+4 more
wiley +1 more source
Aura and osmophobia are associated with the IL1A -889C > T (rs1800587) variant in migraine
Background Migraine belongs to the group of primary headaches, affecting 14.4% of the global population. The pathophysiological mechanisms of migraine involve the interplay between hypothalamic activation, cortical spreading depression ...
Amanda Brant Rocha+7 more
doaj +1 more source
Bistable dynamics underlying excitability of ion homeostasis in neuron models
When neurons fire action potentials, dissipation of free energy is usually not directly considered, because the change in free energy is often negligible compared to the immense reservoir stored in neural transmembrane ion gradients and the long-term ...
Dahlem, Markus A.+2 more
core +2 more sources
Aquaporin-4-dependent K(+) and water transport modeled in brain extracellular space following neuroexcitation. [PDF]
Potassium (K(+)) ions released into brain extracellular space (ECS) during neuroexcitation are efficiently taken up by astrocytes. Deletion of astrocyte water channel aquaporin-4 (AQP4) in mice alters neuroexcitation by reducing ECS [K(+)] accumulation ...
Binder, Devin K+3 more
core +2 more sources
Losing brain networks during death
Abstract Death represents the end of all living organisms. The pattern of brain activity disappearance following death, however, has not been fully elucidated. Here we investigated brain activity dynamics following cardiac arrest using ultra‐high field 11.7 T magnetic resonance imaging (MRI) in longitudinal approach and multi‐modal analyses. Initially,
Han Li+22 more
wiley +1 more source
Abstract Objectives Abdominal pain related disorders of gut–brain interaction (AP‐DGBIs) such as irritable bowel syndrome (IBS) and functional abdominal pain‐not otherwise specified (FAP) are common conditions in children, significantly impacting quality of life.
Jip Groen+17 more
wiley +1 more source
Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group. [PDF]
Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable cerebral gray matter, and are a crucial mechanism of lesion development ...
Ayata, C.+5 more
core +1 more source