Results 141 to 150 of about 1,302,249 (240)

KCl-induced repetitive cortical spreading depression inhibiting trigeminal neuronal firing is mediated by 5-HT_1B/1D and opioid receptors. [PDF]

Cephalalgia, 2022
Supronsinchai W, Hoffmann J, Akerman S, Goadsby PJ.   +3 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Have You Tried Restarting It? Cortical Spreading Depression Shuts Down Seizures by Short-Circuiting Electrical Propagation. [PDF]

Epilepsy Curr, 2022
Shuman T.
europepmc   +1 more source

Disentangling the effect of brain insulin resistance on brain health (BIR‐BrainHealth): Rationale and study protocol

Diabetic Medicine, EarlyView.
Abstract Aims Insulin signalling in the brain is crucial for systemic metabolic regulation and cognitive function. In some individuals, these effects are reduced, a phenomenon referred to as brain insulin resistance (BIR). This condition may contribute to the elevated risk of cognitive decline and dementia in diabetes, yet its prevalence, mechanisms ...
Sabrina Wangler, Peter Sørensen, Konni Kass, Nicole Jaqueline Jensen, Mark Bitsch Vestergaard, Julia Hummel, Ronja Völk, Julie Christine Antvorskov, Flemming Pociot, Jørgen Rungby, Martin Heni, Henrik Bo Wiberg Larsson   +11 more
wiley   +1 more source

Equine vegetative endocarditis and vertebral osteomyelitis due to refractory Erysipelothrix rhusiopathiae infection

Equine Veterinary Education, EarlyView.
Summary Erysipelothrix rhusiopathiae was the causative agent of vegetative endocarditis and vertebral osteomyelitis in a 24‐year‐old Irish draught gelding that presented with prolonged history of intermittent pyrexia and tachycardia. Clinical investigations revealed persistently reduced neck mobility, tachydysrhythmia and episodic pyrexia up to 41°C ...
E. Kolovou, Z. Daobry, Â. J. F. Mendes, G. Weller, S. Radhakrishnan, M. S. I. Sajib, M. Fuentes, F. Zendri, T. Forde, W. Weir, J. Del‐Pozo, D. G. M. Sutton   +11 more
wiley   +1 more source

Migrainous Infarction and Cortical Spreading Depression. [PDF]

Discoveries (Craiova), 2020
Iftikhar W, Cheema FF, Khanal S, Khan QU.   +3 more
europepmc   +1 more source

A Computational Study of Cortical Spreading Depression

, 2016
University of Minnesota Ph.D. dissertation. May 2016. Major: Mathematics. Advisor: Yoichiro Mori. 1 computer file (PDF); viii, 119 pages.Spreading depression (SD) is a pathological phenomenon of the central nervous system in which normal cellular ...
O'Connell, Rosemary
core  

Progesterone receptors regulate susceptibility to spreading depression

Migraine patients often experience sensory symptoms called auras accompanying the headaches. Cortical spreading depression (CSD), a slow-propagating wave of neuroglial depolarization followed by hyperpolarization is proposed to be the neurological ...
Joshi, Suchitra, Baca, Serapio M., Williamson, John, Kapur, Jaideep   +3 more
core   +1 more source

Ion binding sites and intermediate domain closure induced by D‐serine in the GluD1 ligand‐binding domain

The FEBS Journal, EarlyView.
GluD1 belongs to the ionotropic glutamate receptors and has important functions in the brain and brain diseases. We report the crystal structure of the GluD1 ligand‐binding domain with D‐serine and zinc ions. MD simulations supported promiscuous binding of cations and that chloride ions play a stabilizing role. Pro725 seems to hinder interlobe closure,
Flemming Steen Jørgensen, Emma Grosvald Pedersen, Dilip Narayanan, Karla A. Frydenvang, Jette Sandholm Kastrup   +4 more
wiley   +1 more source

Sex-dependent cognitive and behavioral outcomes induced by repetitive cortical spreading depression in mice. [PDF]

J Headache Pain
An Y, Wang Y, Yuan H, Pi C, Yuan C, Na W, He Z, Lin X, Ma Z, Yu S, Li Y.   +10 more
europepmc   +1 more source