Results 121 to 130 of about 10,427 (246)

Have You Tried Restarting It? Cortical Spreading Depression Shuts Down Seizures by Short-Circuiting Electrical Propagation. [PDF]

Epilepsy Curr, 2022
Shuman T.
europepmc   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

The Role of Cortical Spreading Depression in Migraine

Future Neurology, 2015
Bolay, HAYRUNNİSA BOLAY, VURALLI, DOĞA
openaire   +2 more sources

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Sex-dependent cognitive and behavioral outcomes induced by repetitive cortical spreading depression in mice. [PDF]

J Headache Pain
An Y, Wang Y, Yuan H, Pi C, Yuan C, Na W, He Z, Lin X, Ma Z, Yu S, Li Y.   +10 more
europepmc   +1 more source

Cortical spreading depression can be triggered by sensory stimulation in primed wild type mouse brain: a mechanistic insight to migraine aura generation. [PDF]

J Headache Pain, 2022
Hanalioglu S, Taskiran-Sag A, Karatas H, Donmez-Demir B, Yilmaz-Ozcan S, Eren-Kocak E, Gursoy-Ozdemir Y, Dalkara T.   +7 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Cortical spreading depression and multi-territorial cortical infarction following traumatic subdural hematoma: A case report and literature review. [PDF]

Surg Neurol Int
Oda K, Saluja RS, Marcoux J.
europepmc   +1 more source

Efficacy profile of noninvasive vagus nerve stimulation on cortical spreading depression susceptibility and the tissue response in a rat model. [PDF]

J Headache Pain, 2022
Liu TT, Morais A, Takizawa T, Mulder I, Simon BJ, Chen SP, Wang SJ, Ayata C, Yen JC.   +8 more
europepmc   +1 more source