The metabolic consequences of evoked spreading depolarization in brain slices [PDF]
Scientific ReportsSpreading depolarization is a wave of neuronal and glial depolarization that propagates through brain tissue, triggering neuropeptide release and altered blood flow.
Olivia Grech +10 more
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Action Potential Dynamics During Spreading Depolarization [PDF]
CellsSpreading depolarizations (SDs) are major pathophysiological events in several brain diseases, including migraine, brain ischemia, trauma, and epilepsy. However, the electrophysiological detection of SDs remains challenging.
Daria Vinokurova +4 more
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Cerebellar spreading depolarization mediates paroxysmal movement disorder
Cell Reports, 2021 Summary: Paroxysmal kinesigenic dyskinesia (PKD) is the most common paroxysmal dyskinesia, characterized by recurrent episodes of involuntary movements provoked by sudden changes in movement.
Zhi-Qi Xiong, Zhi-Ying Wu
exaly +3 more sources
Contralesional hippocampal spreading depolarization promotes functional recovery after stroke [PDF]
Nature CommunicationsIschemic stroke, brain tissue infarction following obstructed cerebral blood flow, leads to long-term neurological deficits and death. While neocortex is a commonly affected region with established preclinical models, less is known about deeper brain ...
Andrew K. J. Boyce +11 more
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Effect of lacosamide on cortical spreading depolarization in mice [PDF]
The Journal of Headache and PainBackground Antiseizure medications are often used as preventive treatment of migraine in appropriate cases; however, the efficacy of lacosamide (LCM), a sodium channel blocker, in preventing migraine attacks remains unclear.
Chisato Iba +5 more
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Hydrogen inhalation and intrathecal magnesium sulfate ameliorate ischemia by suppressing cortical spreading depolarization in a rat subarachnoid hemorrhage model [PDF]
NeurotherapeuticsThis study investigated whether inhaled hydrogen and intrathecal magnesium could mitigate cortical spreading depolarization and delayed cerebral ischemia in a rat model of subarachnoid hemorrhage.
Toru Yoshiura +15 more
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A systematic review of the causes and consequences of spreading depolarization in neuroinflammation; implications for neurovascular disorders [PDF]
Journal of NeuroinflammationBackground Spreading depolarization (SD) is a wave of neuronal and glial depolarization observed in various neurological conditions, including stroke, traumatic brain injury, subarachnoid haemorrhage, and migraine aura.
Faheem Anwar +7 more
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Oxytocin shortens spreading depolarization-induced periorbital allodynia [PDF]
The Journal of Headache and PainBackground Migraine is among the most prevalent and burdensome neurological disorders in the United States based on disability-adjusted life years. Cortical spreading depolarization (SD) is the most likely electrophysiological cause of migraine aura and ...
Andrea M. Harriott +2 more
doaj +2 more sources
Spreading depolarization activates the cGAS–STING pathway and drives cranial nociception: therapeutic potential of STING modulation [PDF]
The Journal of Headache and PainBackground Spreading depolarization (SD) is a transient wave of near-complete neuronal and glial depolarization in the cortex which underlies migraine aura.
Kadir Oguzhan Soylu +7 more
doaj +2 more sources
Glutamate load fosters spreading depolarization under osmotic stress in brain slices [PDF]
Frontiers in Cellular NeuroscienceIntroductionCerebral edema is a hallmark of lesion progression after acute ischemic stroke (AIS) and a major contributor to the evolution of spreading depolarizations (SDs). SDs trigger extracellular glutamate accumulation and excitotoxic injury, yet the
Rita Frank +7 more
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