Results 21 to 30 of about 295,453 (235)

NMDA receptors sustain but do not initiate neuronal depolarization in spreading depolarization

Neurobiology of Disease, 2020
Spreading depolarization (SD) represents a neurological process characterized by a massive, self-sustaining wave of brain cell depolarization. Understanding its mechanism is important for treating ischemic or hemorrhagic stroke and migraine with aura ...
Yu-Ying Mei, Ming-Hsueh Lee, Ting-Chun Cheng, I-Han Hsiao, Dong Chuan Wu, Ning Zhou   +5 more
doaj   +1 more source

Transient destabilization of interhemispheric functional connectivity induced by spreading depolarization [PDF]

Harvard Data Science Review
Daria A. Lachinova, Maria P. Smirnova, Irina V. Pavlova, Ilya V. Sysoev, Lyudmila V. Vinogradova   +4 more
doaj   +2 more sources

Spreading depression as an innate antiseizure mechanism

Nature Communications, 2021
Spreading depression is a prolonged depolarization in the CNS associated with several neurological diseases. Here the authors demonstrate a reciprocal relationship between spreading depression and seizures in an animal model.
Isra Tamim, David Y. Chung, Andreia Lopes de Morais, Inge C. M. Loonen, Tao Qin, Amrit Misra, Frieder Schlunk, Matthias Endres, Steven J. Schiff, Cenk Ayata   +9 more
doaj   +1 more source

Study of the depolarization current in mineral oils [PDF]

, 2014
Polarization and depolarization current measurement is a non-destructive testing method to study the dielectric properties of insulating materials. Two kinds of mineral oils with different aging time have been measured and compared.
Hao, Miao, Wilson, Gordon, Zhou, Yuan, Jarman, Paul, Chen, George   +4 more
core   +2 more sources

Diversity of cortical activity changes beyond depression during Spreading Depolarizations

Nature Communications, 2023
Spreading depolarizations (SDs) are classically thought to be associated with spreading depression of cortical activity. Here, we found that SDs in patients with subarachnoid hemorrhage produce variable, ranging from depression to booming, changes in ...
Azat Nasretdinov, Daria Vinokurova, Coline L. Lemale, Gulshat Burkhanova-Zakirova, Ksenia Chernova, Julia Makarova, Oscar Herreras, Jens P. Dreier, Roustem Khazipov   +8 more
doaj   +1 more source

Transient astrocytic accumulation of fluorescein during spreading depolarizations

Neurobiology of Disease, 2023
Spreading depolarizations (SDs) occur frequently in acute cerebral injuries. They are characterized by a breakdown of transmembrane ion gradients resulting in a reduced extracellular sodium ([Na+]o) and increased extracellular potassium concentration ([K+
Karl Schoknecht, Johannes Hirrlinger, Jens Eilers   +2 more
doaj   +1 more source

Region-Specific Vulnerability of the Amygdala to Injury-Induced Spreading Depolarization

Biomedicines, 2022
Spreading depolarization (SD), a self-propagated wave of transient depolarization, regularly occurs in the cortex after acute brain insults and is now referred as an important diagnostic and therapeutic target in patients with acute brain injury.
Mariia P. Smirnova, Tatiana M. Medvedeva, Irina V. Pavlova, Lyudmila V. Vinogradova   +3 more
doaj   +1 more source

Specific activation of GluN1-N2B NMDA receptors underlies facilitation of cortical spreading depression in a genetic mouse model of migraine with reduced astrocytic glutamate clearance

Neurobiology of Disease, 2021
Migraine is a common but poorly understood sensory circuit disorder. Mouse models of familial hemiplegic migraine (FHM, a rare monogenic form of migraine with aura) show increased susceptibility to cortical spreading depression (CSD, the phenomenon that ...
Giovanna Crivellaro, Angelita Tottene, Marina Vitale, Marcello Melone, Giorgio Casari, Fiorenzo Conti, Mirko Santello, Daniela Pietrobon   +7 more
doaj   +1 more source

Case report: Delayed posttraumatic cortical laminar necrosis secondary to spreading depolarization induced spreading ischemia from old subarachnoid hemorrhage

Radiology Case Reports, 2022
Cortical laminar necrosis usually occurs secondary to infarcts or hypoxia, however other causes, including hypoglycemia, status epilepticus and immunosuppressive therapy have been reported.
Zakariya Irfanullah, MD, Ayça Özbek Özütemiz, MD, Jetter Robertson, DO, Can Özütemiz, MD   +3 more
doaj   +1 more source

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond [PDF]

Neural Regeneration Research
Khaled Alok, Timothy G. White, Chunyan Li   +2 more
doaj   +2 more sources