First FHM3 mouse model shows spontaneous cortical spreading depolarizations
Annals of Clinical and Translational Neurology, 2020 Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events – the electrophysiological correlate of the migraine aura – in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse ...
Nico A. Jansen +5 more
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Development of a Multiparametric Lidar with the depolarization sensor [PDF]
, 2009 The topic of this work was the design, the realization and the calibration of the depolarization sensor added in the Napoli Lidar (Light Detection and Ranging) system.
Nasti, Libera
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Intravascular Endothelin-1 does not trigger or increase susceptibility to Spreading Depolarizations
The Journal of Headache and Pain, 2020 Objectives Spreading depolarizations (SD) likely manifest as aura in migraineurs. Triggers are unknown although vascular events have been implicated. Direct carotid puncture has been reported to trigger migraine with aura.
Kazutaka Sugimoto +7 more
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Spreading Depolarization in Model of Perfused Slice
, 2022 Simulation of spreading depolarization (SD) for 10 seconds in computer model of perfused brain slice. Average concentrations of extracellular ions and O2 across the depth of the slice with neural spiking activity of a subset (250/36,000) of neurons ...
Craig Kelley (9722018)
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Real-time optical diagnosis of the rat brain exposed to a laser-induced shock wave: observation of spreading depolarization, vasoconstriction and hypoxemia-oligemia. [PDF]
PLoS ONE, 2014 Despite many efforts, the pathophysiology and mechanism of blast-induced traumatic brain injury (bTBI) have not yet been elucidated, partially due to the difficulty of real-time diagnosis and extremely complex factors determining the outcome.
Shunichi Sato +5 more
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Spreading depolarization and angiographic spasm are separate mediators of delayed infarcts [PDF]
, 2023 In DISCHARGE-1, a recent Phase III diagnostic trial in aneurysmal subarachnoid haemorrhage patients, spreading depolarization variables were found to be an independent real-time biomarker of delayed cerebral ischaemia.
Hecht, Nils +16 more
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Understanding Spreading Depression from Headache to Sudden Unexpected Death
Frontiers in Neurology, 2018 Spreading depression (SD) is a neurophysiological phenomenon characterized by abrupt changes in intracellular ion gradients and sustained depolarization of neurons.
Olga Cozzolino +7 more
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Spreading Depolarization bei Patienten mit aneurysmatischer Subarachnoidalblutung
, 2012 Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening disease. In Ger-many, approximately 6000 patients suffer from aSAH every year. Mortality and dis-ability rates of patients reaching medical care are 30% and 30%, respectively.
Winkler, Maren Katharina Laura
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Traveling waves in a model for cortical spreading depolarization with slow–fast dynamics [PDF]
, 2023 Cortical spreading depression and spreading depolarization (CSD) are waves of neuronal depolarization that spread across the cortex, leading to a temporary saturation of brain activity.
David Reyner-Parra +7 more
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Spreading depolarization, a pathophysiological mechanism of stroke and migraine aura
, 2012 Spreading depolarization is a mechanism of abrupt, massive ion translocation between intraneuronal and extracellular space that entails cytotoxic edema in the brain’s gray matter.
Clemens Reiffurth +5 more
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