Results 51 to 60 of about 295,453 (235)

How spreading depolarization can be the pathophysiological correlate of both migraine aura and stroke

, 2020
The term spreading depolarization describes a mechanism of abrupt, massive ion translocation between neurons and the interstitial space, which leads to a cytotoxic edema in the gray matter of the brain.
Dreier, Jens P., Hartings, Jed A., Friedman, Alon, Reiffurth, Clemens, Drenckhahn, Christoph, Windler, Claudia, Herreras, Óscar, MacVicar, Brian, Woitzik, Johannes   +8 more
core   +1 more source

The hemodynamic response of spreading depolarization observed by near infrared spectroscopy after aneurysmal subarachnoid hemorrhage [PDF]

, 2015
Background Electrocorticography (ECoG) in brain-injured patients allows to detect spreading depolarization, a potential mechanism of secondary ischemia. Here, we describe the relationship of spreading depolarization with changes in cerebral hemodynamics ...
Sakowitz, Oliver, Seule, Martin; https://orcid.org/, Unterberg, Andreas, Keller, Emanuela; https://orcid.org/   +3 more
core   +1 more source

Heightened Sensitivity of the Hyperexcitable Occipital Cortex to Spreading Depression: Evidence for State-Dependent Mechanisms of Migraine Aura

Neurology International
Background/Objectives: Cortical spreading depolarization (SD) is recognized as the pathophysiological substrate of migraine aura. Suppression of ongoing cortical activity produced by SD is thought to underlie the transient neurological deficits ...
Tatiana M. Medvedeva, Maria P. Smirnova, Lyudmila V. Vinogradova   +2 more
doaj   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Image_2_Anoxic spreading depolarization in the neonatal rat cortex in vitro.JPEG

, 2023
Anoxic spreading depolarization (aSD) is a hallmark of ischemic injury in the cerebral cortex. In adults, aSD is associated with rapid and nearly complete neuronal depolarization and loss of neuronal functions.
Azat Gainutdinov (6094070), Elvira Juzekaeva (6094067), Marat Mukhtarov (6094073), Roustem Khazipov (6094076)   +3 more
core   +1 more source

Vesicular HMGB1 release from neurons stressed with spreading depolarization enables confined inflammatory signaling to astrocytes

Journal of Neuroinflammation, 2023
The role of high mobility group box 1 (HMGB1) in inflammation is well characterized in the immune system and in response to tissue injury. More recently, HMGB1 was also shown to initiate an “inflammatory signaling cascade” in the brain parenchyma after a
Zeynep Kaya, Nevin Belder, Melike Sever-Bahcekapili, Buket Donmez-Demir, Şefik Evren Erdener, Naz Bozbeyoglu, Canan Bagci, Emine Eren-Kocak, Muge Yemisci, Hulya Karatas, Esra Erdemli, Ihsan Gursel, Turgay Dalkara   +12 more
doaj   +1 more source

Neuromorphic Electronics for Intelligence Everywhere: Emerging Devices, Flexible Platforms, and Scalable System Architectures

Advanced Materials, EarlyView.
The perspective presents an integrated view of neuromorphic technologies, from device physics to real‐time applicability, while highlighting the necessity of full‐stack co‐optimization. By outlining practical hardware‐level strategies to exploit device behavior and mitigate non‐idealities, it shows pathways for building efficient, scalable, and ...
Kapil Bhardwaj, Roshni Satheesh Babu, Yuxin Xia, Eva Bestelink, Radu Sporea, Nikos Hastas, Ioannis Zeimpekis, Dimitra G. Georgiadou, Sayani Majumdar   +8 more
wiley   +1 more source

ECoG-based short-range recurrent stimulation techniques to stabilize tissue at risk of progressive damage: Theory based on clinical observations [PDF]

, 2009
We introduce theoretical concepts based on chaos control to stabilize in acute stroke the tissue at risk of progressive damage by preventing adverse effects of waves of mass neuronal depolarization.
Felix M. Schneider, Markus A. Dahlem, Eckehard Schoell, Jens P. Dreier, Anthony J. Strong   +4 more
core   +1 more source

Image_1_Anoxic spreading depolarization in the neonatal rat cortex in vitro.JPEG

, 2023
Anoxic spreading depolarization (aSD) is a hallmark of ischemic injury in the cerebral cortex. In adults, aSD is associated with rapid and nearly complete neuronal depolarization and loss of neuronal functions.
Azat Gainutdinov (6094070), Elvira Juzekaeva (6094067), Marat Mukhtarov (6094073), Roustem Khazipov (6094076)   +3 more
core   +1 more source