Dibucaine mitigates spreading depolarization in human neocortical slices and prevents acute dendritic injury in the ischemic rodent neocortex. [PDF]
PLoS ONE, 2011 Spreading depolarizations that occur in patients with malignant stroke, subarachnoid/intracranial hemorrhage, and traumatic brain injury are known to facilitate neuronal damage in metabolically compromised brain tissue.
W Christopher Risher +4 more
doaj +2 more sources
Migraine Aura, Transient Ischemic Attacks, Stroke, and Dying of the Brain Share the Same Key Pathophysiological Process in Neurons Driven by Gibbs–Donnan Forces, Namely Spreading Depolarization [PDF]
Frontiers in Cellular Neuroscience, 2022 Neuronal cytotoxic edema is the morphological correlate of the near-complete neuronal battery breakdown called spreading depolarization, or conversely, spreading depolarization is the electrophysiological correlate of the initial, still reversible phase ...
Coline L. Lemale +17 more
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The Role of Cell Volume in the Dynamics of Seizure, Spreading Depression, and Anoxic Depolarization. [PDF]
PLoS Computational Biology, 2015 Cell volume changes are ubiquitous in normal and pathological activity of the brain. Nevertheless, we know little of how cell volume affects neuronal dynamics. We here performed the first detailed study of the effects of cell volume on neuronal dynamics.
Ghanim Ullah +4 more
doaj +2 more sources
Anoxic spreading depolarization in the neonatal rat cortex in vitro
Frontiers in Cellular Neuroscience, 2023 Anoxic spreading depolarization (aSD) is a hallmark of ischemic injury in the cerebral cortex. In adults, aSD is associated with rapid and nearly complete neuronal depolarization and loss of neuronal functions.
Azat Gainutdinov +5 more
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Inflammatory response of leptomeninges to a single cortical spreading depolarization [PDF]
The Journal of Headache and PainBackground Neurogenic meningeal inflammation is regarded as a key driver of migraine headache. Multiple evidence show importance of inflammatory processes in the dura mater for pain generation but contribution of the leptomeninges is less clear.
Anna A. Karan +4 more
doaj +2 more sources
Activation of central and peripheral transient receptor potential melastatin 8 increases susceptibility to spreading depolarization and facilitates trigeminal neuroinflammation [PDF]
The Journal of Headache and PainBackground Transient receptor potential melastatin 8 (TRPM8), a gene encoding a nonselective cation channel responsive to cold stimuli, has been implicated in migraine susceptibility.
Tzu-Ting Liu +8 more
doaj +2 more sources
Quantitative, real-time imaging of spreading depolarization-associated neuronal ROS production [PDF]
Frontiers in Cellular NeuroscienceSpreading depolarization (SD) causes a massive neuronal/glial depolarization, disturbs ionic homeostasis and deranges neuronal network function. The metabolic burden imposed by SD may also generate marked amounts of reactive oxygen species (ROS).
Marc André Ackermann +3 more
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Correction: Oxytocin shortens spreading depolarization-induced periorbital allodynia [PDF]
The Journal of Headache and PainAndrea M. Harriott +2 more
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Spreading depolarization: A phenomenon in the brain [PDF]
, 2022 In 1944, the physiologist Leão while studying epilepsy in the rabbit noticed a sudden temporary cessation of electrocorticographic (ECoG) activity accompanied with a large negative slow potential change recorded by extracellular electrodes, that is later
Tuncer, Mehmet Cudi +3 more
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Genome-wide DNA methylation analysis in an antimigraine-treated preclinical model of cortical spreading depolarization [PDF]
, 2023 Background: Cortical spreading depolarization, the cause of migraine aura, is a short-lasting depolarization wave that moves across the brain cortex, transiently suppressing neuronal activity.
Queirós, Ana C. +9 more
core +1 more source