British Journal of Pharmacology, EarlyView.Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito +6 more
wiley +1 more source
Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women
Clinical Endocrinology, EarlyView.ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan +14 more
wiley +1 more source
Neurobiology of Disease, 2014 The brain responds differently to environmental and internal signals that relate to the stage of development of neural systems. While genetic and epigenetic factors contribute to a premorbid state, hormonal fluctuations in women may alter the set point ...
D. Borsook +8 more
doaj
Validating a Computational Framework for Ionic Electrodiffusion with Cortical Spreading Depression as a Case Study. [PDF]
eNeuro, 2022 Ellingsrud AJ +5 more
europepmc +1 more source
Cortical Spreading Depression Causes a Long-Lasting Decrease in Cerebral Blood Flow and Induces Tolerance to Permanent Focal Ischemia in Rat Brain [PDF]
, 2003 Tatsuo Otori +2 more
openalex +1 more source
Myeloid PD‐1 Regulates Astrocyte Development and Leads to Active Behaviours
Cell Proliferation, EarlyView.During early neurodevelopment, PD‐1 ablation in myeloid cells influences myeloid proliferation/differentiation and causes sustained astrocyte overproliferation. PD‐1f/f; LysM‐Cre mice showed elevated astrocyte gene expression and behavioural changes.
Jie Qin +6 more
wiley +1 more source
Analysis of Receptor’s Distribution in Entorhinal Cortex after Induction of Spreading Depression in Juvenile Rats [PDF]
, 2015 Spreading depression (SD), discovered by Leao in 1944, is a pathophysiological wave which propagates slowly in the brain (3 mm/min) and cause dramatic ionic and hemodynamic changes.
Alizadeh, L., Ghaemi, A., Lotfinia, A.A.
core
Symptom network analysis of prefrontal seizures
Epilepsia, EarlyView.Abstract Objective Prefrontal seizures pose significant challenges in accurately identifying the complex interactions between clinical manifestations and brain electrophysiological activities. This proof‐of‐concept study aims to propose a new approach to rigorously support electroclinical reasoning in the field of epilepsy.
Christophe Gauld +3 more
wiley +1 more source
Two‐year outcomes of epicranial focal cortex stimulation in pharmacoresistant focal epilepsy
Epilepsia, EarlyView.Abstract Objective This study was undertaken to report on the long‐term safety and efficacy of epicranial focal cortex stimulation (FCS) using the EASEE device as adjunctive neuromodulatory therapy in improving seizure control in adults with pharmacoresistant epilepsy originating from one predominant epileptogenic zone.
Andreas Schulze‐Bonhage +12 more
wiley +1 more source
Impaired Vascular Reactivity of Isolated Rat Middle Cerebral Artery after Cortical Spreading Depression in Vivo [PDF]
, 2004 Iris A. Seitz +2 more
openalex +1 more source