Results 171 to 180 of about 53,540 (338)

Ion channels in migraine disorders [PDF]

, 2018
Pietrobon, Daniela
core   +1 more source

Development of a preclinical testing platform for clinically relevant therapy for Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Patients with drug‐resistant epilepsy, including Dravet syndrome, are frequently prescribed multiple antiseizure medications. Nevertheless, people with Dravet syndrome often have inadequate seizure control, and there is an ongoing unmet clinical need to identify novel therapeutics.
Jeffrey A. Mensah, Kyle E. Thomson, Jennifer L. Huff, Tia Freeman, Christopher A. Reilly, Joseph E. Rower, Cameron S. Metcalf, Karen S. Wilcox   +7 more
wiley   +1 more source

KCl-induced repetitive cortical spreading depression inhibiting trigeminal neuronal firing is mediated by 5-HT_1B/1D and opioid receptors. [PDF]

Cephalalgia, 2022
Supronsinchai W, Hoffmann J, Akerman S, Goadsby PJ.   +3 more
europepmc   +1 more source

Direct, Live Imaging of Cortical Spreading Depression and Anoxic Depolarisation Using a Fluorescent, Voltage-Sensitive Dye [PDF]

, 2007
Eszter Farkas, Rosalind Pratt, Frank Sengpiel, Tihomir P. Obrenovitch   +3 more
openalex   +1 more source

Depolarization increases cellular light transmission [PDF]

, 2008
Application of optical methods to human brain tissue in vivo, e.g., measuring oxyhemoglobin and deoxyhemoglobin concentration changes with near-infrared spectroscopy (NIRS), requires the a priori assumption that background optical properties remain ...
Haruki Toriumi, Jemal Tatarishvili, Minoru Tomita, Miyuki Unekawa, Norihiro Suzuki, Takashi Osada, Yutaka Tomita   +6 more
core   +1 more source

Elevation in body temperature may increase susceptibility to cortical spreading depression in a rat model

Neuroscience Research
One characteristic of migraine is recurrent headache attacks, which are known to be induced by changes in climatic variables such as atmospheric pressure, humidity, and outside temperature.
Eiji Kitamura, Naomi Kanazawa, Takahiro Iizuka, Kazutoshi Nishiyama   +3 more
doaj  

Type I interferon signalling and interferon‐responsive microglia in health and disease

The FEBS Journal, EarlyView.
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya, Aysha M. Bhojwani‐Cabrera   +1 more
wiley   +1 more source

A Quantitative Model of Cortical Spreading Depression Due to Purinergic and Gap-Junction Transmission in Astrocyte Networks [PDF]

, 2008
Max R. Bennett, Les Farnell, W.G. Gibson
openalex   +1 more source

Multidomain interventions for prevention of dementia: Achievements, challenges and future perspectives

Geriatrics &Gerontology International, EarlyView.
Multidomain interventions for preventing cognitive decline have shown promising effects in delaying cognitive deterioration among older adults. This review provides an overview of published and ongoing multidomain intervention trials, highlighting current challenges and future directions.
Takashi Sakurai, Taiki Sugimoto, Hidenori Arai   +2 more
wiley   +1 more source

The Role of Electrode Size on the Incidence of Spreading Depression and on Cortical Cerebral Blood Flow as Measured by H₂ Clearance

, 1992
Marleen Verhaegen, Michael M. Todd, David S. Warner, Bruce James, Julie B. Weeks   +4 more
openalex   +1 more source