Results 231 to 240 of about 28,652 (329)

Temporal Interference Stimulation: Mechanisms, Optimization, Validation, and Clinical Prospects—A Comprehensive Review

open access: yesWIREs Computational Statistics, Volume 17, Issue 3, September 2025.
This schematic highlights the key developments discussed in this review paper on Temporal Interference Stimulation (TIS), a non‐invasive technique for deep brain stimulation using interfering high‐frequency electric fields. Topics include optimization strategies, computational modelling, experimental findings, comparisons with other neuromodulation ...
Hossein Soroushi   +4 more
wiley   +1 more source

Astroglial CB1 Reveal Sex‐Specific Synaptic Effects of Amphetamine

open access: yesGlia, Volume 73, Issue 8, Page 1673-1691, August 2025.
Main Points Astroglial CB1 mediate long‐term depression in the NAc through purine release. Amphetamine occludes LTD in male mice by inducing the saturation of A1 receptors. Astroglial CB1 mediate behavioral amphetamine effects in males, but not in females.
Yamuna Mariani   +15 more
wiley   +1 more source

Subtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex‐Specific Differences in Amyloidosis and Microglia in a Pre‐Symptomatic Mouse Model of Alzheimer‐Like Pathology

open access: yesGlia, Volume 73, Issue 8, Page 1727-1745, August 2025.
Main Points In a pre‐symptomatic mouse model of Alzheimer disease, despite higher amyloid‐β load females display less plaques than males. More efficient synaptic transmission as well as less microgliosis point to better early coping with pathogenesis in females.
Thomas Chaigneau   +7 more
wiley   +1 more source

Using Extreme Value Statistics to Reconceptualize Psychopathology as Extreme Deviations From a Normative Reference Model

open access: yesHuman Brain Mapping, Volume 46, Issue 11, August 1, 2025.
Overview of our approach for extreme value statistics. First, we fit a normative model to imaging phenotypes, before employing a ‘peaks‐over‐threshold’ approach widely used in meteorology and finance. This allows us to model tail dependencies and provides a multivariate measure of extremely dependence through a tail pairwise dependency matrix (TPDM ...
Charlotte Fraza   +3 more
wiley   +1 more source

Astrocyte in Neurological Disease: Pathogenesis and Therapy

open access: yesMedComm, Volume 6, Issue 8, August 2025.
This review provides comprehensive overview of astrocytes in neurological disorders. Astrocytes contribute to neurological disorders via A1/A2 polarization, inducing neuroinflammation, synaptic, and BBB dysfunction. Metabolic disturbances in glucose, lipid, and amino acid pathways leading to oxidative stress and mitochondrial damage.
Meihui Huang   +4 more
wiley   +1 more source

Post‐COVID‐19 condition: clinical phenotypes, pathophysiological mechanisms, pathology, and management strategies

open access: yesThe Journal of Pathology, Volume 266, Issue 4-5, Page 369-389, August 2025.
Abstract Post‐COVID‐19 condition (PCC), also known as long COVID, is a complex multiple organ system condition that can develop and persist for months after acute COVID‐19. PCC encompasses a wide range of symptoms, resulting in heterogeneous clinical manifestations. These manifestations likely arise from diverse underlying pathophysiological mechanisms,
Larissa E Vlaming‐van Eijk   +5 more
wiley   +1 more source

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