Results 121 to 130 of about 340,216 (249)

Molecular dynamics of the host response to Streptococcus pneumoniae pneumonia in baboons

Animal Models and Experimental Medicine, EarlyView.
Using an established, clinically relevant nonhuman primate model of S. pneumoniae pneumonia, this study aims to identify novel potential molecular diagnostic and therapeutic targets using peripheral blood bulk transcriptomic, unbiased proteomic, and cytokine measurements. The constructed models were highly accurate in classifying bacterial pneumonia in
Bryan D. Kraft, Ashlee M. Valente, Ephraim L. Tsalik, Micah T. McClain, Marshall Nichols, Thomas W. Burke, Ricardo Henao, Erik J. Soderblom, J. Will Thompson, M. Arthur Moseley, Lori L. Hudson, Timothy Veldman, Olga M. Better, Mert Aydin, Anna Mazur, Karen E. Welty‐Wolf, Claude A. Piantadosi, Geoffrey S. Ginsburg, Christopher W. Woods   +18 more
wiley   +1 more source

Disruption of ovarian function and induction of apoptosis in female mice by Brefeldin A: Mechanistic insights into reproductive toxicity

Animal Models and Experimental Medicine, EarlyView.
Brefeldin A (BFA) significantly inhibits oocyte release and induces apoptosis in ovarian granulosa cells by disrupting follicular development. It downregulates proliferation‐associated genes, reduces SIRT1/SIRT6 proteins, and upregulates cell cycle inhibitors P21 and P16. Additionally, BFA impairs estrogen synthesis and affects ovarian function through
Yao Jiang, Meng Lv, Haidan Fan, Yonghua Shi, Tao Wang, Penghao Wang, Xiaolong Yuan, Fei Gao, Bin Ma   +8 more
wiley   +1 more source

Elevated serum OX40L is a biomarker for identifying corticosteroid resistance in pediatric asthmatic patients

, 2019
Suli Ma, Lei Zhang
openalex   +1 more source

Peptide/Antibody–Drug Conjugates for Therapeutic Applications in Inflammatory Disease

Advanced NanoBiomed Research, EarlyView.
Peptide/antibody–drug conjugates (PADCs) combine ligand specificity and cleavable linkers to deliver drugs precisely to disease sites with minimal toxicity. While current approvals focus on oncology, this review examines their untapped potential in inflammatory diseases, detailing mechanisms of targeted delivery and highlighting advances that position ...
Yeongji Jang, Jiwoong Choi, Youngri Ryu, Hyun Kyu Song, Man Kyu Shim, Yoosoo Yang   +5 more
wiley   +1 more source

Associations Between Changes in Pain Sensitization and Disease Activity Following Disease‐Modifying Antirheumatic Drug Therapy in Established Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Abnormalities in pain regulatory mechanisms are common in patients with rheumatoid arthritis (RA). We investigated whether pain sensitization changes after treatment with a disease‐modifying antirheumatic drug (DMARD) and explored associations between changes in pain sensitization and disease activity.
Burcu Aydemir, Andrew C. Heisler, Lutfiyya N. Muhammad, Jing Song, Alyssa Wohlfahrt, Daniel J. Clauw, Wendy Marder, Marcy B. Bolster, Clifton O. Bingham, Tuhina Neogi, Yvonne C. Lee   +10 more
wiley   +1 more source

Comparing the Efficacy of Local Corticosteroid Injection and High-Intensity Laser Therapy in Patients with De Quervain Tenosynovitis [PDF]

پزشکی بالینی ابن سینا
Background and Objective: De Quervain's tenosynovitis is one of the common causes of wrist pain. The present study aimed to compare the effectiveness of high-power laser therapy and local corticosteroid injection in the treatment of De Quervain's ...
Mohammad Reza Nikoo, Motahareh Pourgholam, Zahra Basiri   +2 more
doaj  

American College of Rheumatology Guidance Statement for Diagnosis and Management of VEXAS Developed by the International VEXAS Working Group Expert Panel

Arthritis &Rheumatology, EarlyView.
Objective Vacuoles E1 enzyme X‐linked autoinflammatory somatic syndrome (VEXAS) is a recently identified rare genetic disorder associated with somatic mutations in the UBA1 gene. VEXAS presents with a combination of inflammatory and hematologic manifestations, leading to increased morbidity and mortality.
Arsene Mekinian, Sophie Georgin‐Lavialle, Marcela A. Ferrada, Sinisa Savic, Matthew J. Koster, Olivier Kosmider, Thibault Comont, Mael Heilblig, Juan I. Arostegui, Annmarie Bosco, Rim Bourguiba, Katherine R. Calvo, Catherine Cargo, Chiara Cattaneo, François Chasset, Henrique Coelho, Corrado Campochiaro, Francesca Crisafulli, Stephanie Ducharme‐Benard, Raquel Faria, Franco Franceschini, Micol Frassi, Emma M. Groarke, Carmelo Gurnari, Yervand Hakobyan, Yvan Jamilloux, Ciprian Jurcut, Yohei Kirino, Austin Kulasekararaj, Hiroyoshi Kunimoto, Lauren M. Madigan, Heřman F. Mann, Chiara Marvisi, Marcin Milchert, Sara Morais, Katja Sockel, Francesco Muratore, Hideaki Nakajima, Mrinal M. Patnaik, Luísa Regadas, Marie Robin, Abraham Rutgers, Carlo Salvarani, Anthony M. Sammel, Joerg Seebach, Pierre Sujobert, Alessandro Tomelleri, Geoffrey Urbanski, Frédéric Vandergheynst, Romana Vieira, David S. Viswanatha, Ewa Więsik‐Szewczyk, Elisa Diral, Benjamin Terrier, Bhavisha A. Patel, Pierre Fenaux, Peter C. Grayson, David B. Beck, on behalf of the International VEXAS working group, and with endorsement of EuroBloodNet, the European Reference Network in Rare Hematological Diseases, Heřman Mann, Benjamin Terrier, François Chasset, Sophie Georgin Lavialle, Alessandro Tomelleri, Campochiaro Corrado, Carlo Salvarani, Francesca Crisafulli, Franco Franceschini, Micol Frassi, Yohei Kirino, Ewa Więsik‐Szewczyk, Marcin Milchert, Raquel Faria, Ciprian Jurcut, Joerg Seebach, Sinisa Savic, David Beck, Lauren Madigan, Matthew Koster, Patnaik Mrinal, Olivier Kosmider, Pierre Sujobert, Juan I. Arostegui, Catherine Cargo, David Viswanatha, Yervand Hagopian, Mael Heilblig, Pierre Fenaux, Thibault Comont, Bruno Alessandro, Chiara Cattaneo, Elisa Diral, Sara Morais, Austin Kulasekarara, Emma Groarke, Katherine Calvo, Patel Bhavisha, Anthony Sammel, Arsene Mekinian, Benjamin Terrier, Marie Robin, Sophie Georgin Lavialle, Katja Sockel, Yvan Jamilloux, Carmelo Gurnari, Henrique Coelho, Romana Vieira, Rim Bourguiba, Marcela Ferrada, Peter Grayson   +111 more
wiley   +1 more source

Serum cytokine profiling differentiates underlying diseases in cytokine storm syndrome

Arthritis &Rheumatology, Accepted Article.
Objective Cytokine storm syndrome (CSS), commonly associated with hemophagocytic lymphohistiocytosis (HLH), is a fatal hyperinflammatory syndrome. Differentiating the underlying diseases responsible for CSS is essential for timely therapeutic decisions. This study explored the clinical usefulness of serum cytokine profiling in distinguishing underlying
Shuya Kaneko, Maho Hatano, Asami Shimbo, Futaba Miyaoka, Hitoshi Irabu, Yuko Akutsu, Yuko Hayashi, Mao Mizuta, Yasuo Nakagishi, Keiji Akamine, Naomi Iwata, Kenji Furuno, Takayuki Tanaka, Kazuyuki Ueno, Shuhei Fujita, Koji Yokoyama, Toshinori Minato, Kazushi Izawa, Takahiro Yasumi, Tadashi Matsubayashi, Tadashi Hosoya, Hiroki Nishikawa, Junya Fujimura, Ryoko Asano, Yuko Sugita, Kenichi Watanabe, Anna Kobayashi, Takuya Endo, Katsuhide Eguchi, Ryuta Nishikomori, Ryuhei Yasuoka, Takaki Asano, Miyako Kanno, Kazuya Hamada, Yuji Fujita, Daisuke Hayashi, Shojiro Watanabe, Takeshi Shiba, Shinsuke Yasuda, Masaaki Mori, Hirokazu Kanegane, Masatoshi Takagi, Masaki Shimizu   +42 more
wiley   +1 more source

Effect of corticosteroids on haemoglobinuria resolution among children with blackwater fever at Soroti regional referral hospital, Uganda: a retrospective cohort study. [PDF]

Malar J
Odiit A, Lubogo P, Ochora M, Ebiju I, Opito R.   +4 more
europepmc   +1 more source

Spermidine reproduces the anti‐inflammatory effects of intermittent fasting and prevents urate and calcium pyrophosphate crystal‐induced inflammation

Arthritis &Rheumatology, Accepted Article.
Background Gout due to the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent flares that rely on interleukin (IL)‐1β via activation of the NLRP3 inflammasome.
Chinh Nghia Pham, Florence Castelli, Flora Finet, Charles Leroy, Céline Chollet, Twinu Wilson Chirayath, Subhalaxmi Moitra, Mylène Zarka, Agnès Ostertag, François Brial, Christèle Combes, Augustin Latourte, Thomas Bardin, François Fenaille, Pascal Richette, Hang Korng Ea   +15 more
wiley   +1 more source