Results 61 to 70 of about 516,590 (413)

Reduced steroid activation of elephant shark glucocorticoid and mineralocorticoid receptors after inserting four amino acids from the DNA-binding domain of lamprey corticoid receptor-1 [PDF]

arXiv, 2023
Atlantic sea lamprey contains two corticoid receptors (CRs), CR1 and CR2, that are identical except for a four amino acid insert (Thr-Arg-Gln-Gly) in the CR1 DNA-binding domain (DBD). Steroids are stronger transcriptional activators of CR2 than of CR1 suggesting that the insert reduces the transcriptional response of lamprey CR1 to steroids. The DBD in
arxiv  

Corticosteroids and the brain [PDF]

Endocrine Abstracts, 2017
The brain is continuously exposed to varying levels of adrenal corticosteroid hormones such as corticosterone in rodents and cortisol in humans. Natural fluctuations occur due to ultradian and circadian variations or are caused by exposure to stressful situations. Brain cells express two types of corticosteroid receptors, i.e.
openaire   +5 more sources

Aldosterone and Dexamethasone Activate African Lungfish Mineralocorticoid Receptor: Increased Activation After Removal of the Amino-Terminal Domain [PDF]

arXiv, 2021
Aldosterone, the main physiological mineralocorticoid in humans and other terrestrial vertebrates, first appears in lungfish, which are lobe-finned fish that are forerunners of terrestrial vertebrates. Aldosterone activation of the MR regulates internal homeostasis of water, sodium and potassium, which was critical in the conquest of land by ...
arxiv  

Association of Corticosteroid Treatment With Outcomes in Adult Patients With Sepsis: A Systematic Review and Meta-analysis

JAMA Internal Medicine, 2019
Importance Although corticosteroids are widely used for adults with sepsis, both the overall benefit and potential risks remain unclear. Objective To conduct a systematic review and meta-analysis of the efficacy and safety of corticosteroids in patients ...
Fang Fang, Yu Zhang, Jingjing Tang, L. Lunsford, Tiangui Li, Rongrui Tang, Jialing He, P. Xu, A. Faramand, Jianguo Xu, C. You   +10 more
semanticscholar   +1 more source

Comparing the effectiveness of small-particle versus large-particle inhaled corticosteroid in COPD [PDF]

, 2014
Dirkje S Postma,1 Nicolas Roche,2 Gene Colice,3 Elliot Israel,4 Richard J Martin,5 Willem MC van Aalderen,6 Jonathan Grigg,7 Anne Burden,8 Elizabeth V Hillyer,8 Julie von Ziegenweidt,8 Gokul Gopalan,9 David Price8,10 1University of Groningen, Department ...
Burden, A, Colice, G, Gopalan, G, Grigg, J, Hillyer, EV, Israel, E, Martin, RJ, Postma, DS, Price, D, Roche, N, van Aalderen, WMC, von Ziegenweidt, J   +11 more
core   +6 more sources

Decline of COPD exacerbations in clinical trials over two decades -- a systematic review and meta-regression [PDF]

Respiratory Research 20:186, 2019, 2019
BACKGROUND: An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. A more systematic understanding would help to improve the design and interpretation of COPD trials.
arxiv   +1 more source

Inhaled Corticosteroids [PDF]

Pharmaceuticals, 2010
Inhaled corticosteroids (ICS) are the most effective controllers of asthma. They suppress inflammation mainly by switching off multiple activated inflammatory genes through reversing histone acetylation via the recruitment of histone deacetylase 2 (HDAC2).
openaire   +5 more sources

Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study

Intensive Care Medicine, 2018
PurposeTo determine clinical predictors associated with corticosteroid administration and its association with ICU mortality in critically ill patients with severe influenza pneumonia.MethodsSecondary analysis of a prospective cohort study of critically ...
G. Moreno, Alejandro Rodríguez, L. Reyes, Josep Gómez, J. Solé-Violán, E. Díaz, M. Bodí, S. Trefler, J. Guardiola, J. C. Yébenes, Á. Soriano, J. Garnacho-Montero, L. Socias, M. del Valle Ortíz, E. Correig, J. Marín-Corral, Montserrat Vallverdú-Vidal, M. Restrepo, A. Torres, I. Martín-Loeches   +19 more
semanticscholar   +1 more source

New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma [PDF]

, 2017
Introduction: Inhaled corticosteroids (ICS) alone or in combination with an inhaled long-acting beta2-agonist (LABA) are the preferred long-term treatment for adults and adolescents with symptomatic asthma.
Thomson, Neil C.
core   +1 more source

Accessible ecophysiological tools for seabird conservation

Aquatic Conservation: Marine and Freshwater Ecosystems, Volume 32, Issue 12, Page 1983-2002, December 2022., 2022
Abstract Seabirds are the most endangered avian taxa on Earth, with over a third of species globally threatened. To help slow their decline, conservation physiology seeks to determine how seabird responses to climatic and anthropogenic threats influence demographic processes, but it is not widely utilized in monitoring.
Edin A. Whitehead, Brendon J. Dunphy
wiley   +1 more source