Results 61 to 70 of about 313,604 (267)

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Arthritis Care &Research, Accepted Article.
Objective The objective is to describe and compare demographic, clinical and serological characteristics of systemic sclerosis (SSc) patients according to ethnic background. Methods Participants enrolled in the Canadian Scleroderma Research Group cohort who self‐identified to a single ethnicity group were included.
Danick Goulet, Camille Guertin, Maggie Larché, Isabelle Ferdinand, Marie Hudson, May Y. Choi, Mohammed Osman, Janet Pope, Carter Thorne, Murray Baron, Canadian Scleroderma Research Group, M. Baron, M.Y. Choi, P. Docherty, P.R. Fortin, M. Fritzler, G. Gyger, S. Hoa, M. Hudson, A. Ikic, N. Jones, H. Kim, N. Khalidi, M. Larché, S. LeClercq, N. Maltez, A. Man, A. Masetto, J. Pope, D. Robinson, E. Sutton, C. Thorne, Sasha Bernatsky, Sabrina Hoa   +33 more
wiley   +1 more source

The Efficacy of Oral/Intravenous Corticosteroid Use in COVID-19 Patients: A Systematic Review

Journal of Experimental Pharmacology
Irma Rahayu Latarissa,1,2 Farida Rendrayani,1 Ghina Nadhifah Iftinan,2 Cecep Suhandi,3 Anna Meiliana,1,4 Ida Paulina Sormin,5,6 Melisa Intan Barliana,7,8 Keri Lestari1,2,8 1Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy ...
Latarissa IR, Rendrayani F, Iftinan GN, Suhandi C, Meiliana A, Sormin IP, Barliana MI, Lestari K   +7 more
doaj  

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Does intra-articular injection of antimicrobials alongside corticosteroids or other medications reduce the risk of synovial sepsis?

Veterinary Evidence, 2019
PICO question In horses, does treatment with intra-articular antimicrobials concurrently with intra-articular corticosteroids reduce the risk of iatrogenic synovial sepsis compared to intra-articular corticosteroids alone?
Helen R Braid
doaj   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Toll-Like Receptor 2 Release by Macrophages: An Anti-inflammatory Program Induced by Glucocorticoids and Lipopolysaccharide

Frontiers in Immunology, 2019
Glucocorticoids (GCs) are widely prescribed therapeutics for the treatment of inflammatory diseases, and endogenous GCs play a key role in immune regulation.
Jessica Hoppstädter, Anna Dembek, Rebecca Linnenberger, Charlotte Dahlem, Ahmad Barghash, Claudia Fecher-Trost, Gregor Fuhrmann, Marcus Koch, Annette Kraegeloh, Hanno Huwer, Alexandra K. Kiemer   +10 more
doaj   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

The Effect of Topical Application of 0.1% Betamethasone Ointment on the Peritoneal Adhesion and Inflammation Following Laparotomy: A Histopathological Animal Experiment

Pharmaceutical and Biomedical Research, 2019
Adhesion band is one of the most important challenges after the operation. Regarding to the use of corticosteroid medications in inflammatory conditions, no studies have been conducted on the topical application, even though limited success have been ...
Seyed Abdollah Mousavi, Seyed Jaber Mousavi, Maryam Ghasemi, Hooshang Akbari, Ali Haqqani   +4 more
doaj  

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source