Results 91 to 100 of about 81,990 (314)
Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders
Andrology, EarlyView.Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret +5 more
wiley +1 more source
Australian Veterinary Journal, EarlyView.This study appraises recent research to critically evaluate knowledge on the factors that influence decisions around the release of rehabilitated koalas to fire‐affected home sites. Availability of koala release sites could be compromised at times in the future by the increasing incidence of large and intense bushfires due to climate change.
D Hill, DP Higgins
wiley +1 more source
F1000ResearchBackground Good animal welfare is important ethically but also to ensure animals provide valid scientific models. Despite thousands of amphibians in research laboratories there is minimal quantitative evidence pertaining to their management and welfare ...
Charlotte A Hosie +4 more
doaj
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
Advancing antihypertensive drug development
British Journal of Pharmacology, EarlyView.Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu +5 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Inflammation is vital for defence against injury and infection, but excessive inflammation can lead to tissue damage and disease. The central nervous system (CNS) helps regulate immune responses through neuroendocrine pathways, such as the hypothalamic–pituitary–adrenal axis and the anti‐inflammatory reflex, which limit systemic inflammation.
Evelin C. Cárnio +5 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Although perivascular adipose tissue (PVAT) contains substances with contractile properties, its actions on the vascular tone are associated with the release of anticontractile substances. We hypothesize that procontractile PVAT products also exert direct effects on vascular tone. Experimental Approach Thoracic aortas from Wistar
Leonardo Gomes‐Pereira +1 more
wiley +1 more source
EFFECTS OF CORTICOSTERONE, HYDROCORTISONE, AND CORTICOTROPIN ON PRODUCTION OF ANTIBODIES IN RABBITS [PDF]
, 1955 Edward H. Kass +2 more
openalex +1 more source
Clinical Endocrinology, EarlyView.ABSTRACT Introduction Worldwide, combined 17‐hydroxylase/17,20‐lyase deficiency (CYP17D) is a rare form of congenital adrenal hyperplasia, but it is the second most prevalent type in Brazil. An absence of sexual differentiation and hypergonadotropic hypogonadism arise from a reduction in the usual pattern of sex steroid formation in the adrenals and ...
Rafaela Fontenele +9 more
wiley +1 more source
TREATMENT OF ADDISON'S DISEASE WITH DESOXY-CORTICOSTERONE ACETATE, A SYNTHETIC ADRENAL CORTICAL HORMONE (PRELIMINARY REPORT) 1 [PDF]
, 1939 George W. Thorn +2 more
openalex +1 more source