Results 41 to 50 of about 2,012,837 (280)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

RETRACTED ARTICLE: Sulfur availability regulates plant growth via glucose-TOR signaling

Nature Communications, 2017
Growth of eukaryotic cells is regulated by the target of rapamycin (TOR). The strongest activator of TOR in metazoa is amino acid availability. The established transducers of amino acid sensing to TOR in metazoa are absent in plants. Hence, a fundamental
Yihan Dong, Marleen Silbermann, Anna Speiser, Ilaria Forieri, Eric Linster, Gernot Poschet, Arman Allboje Samami, Mutsumi Wanatabe, Carsten Sticht, Aurelio A. Teleman, Jean-Marc Deragon, Kazuki Saito, Rüdiger Hell, Markus Wirtz   +13 more
doaj   +1 more source

The Comparative Value of Serum Angiotensin Converting Enzyme (ACE) and Lysozyme and the Use of Polyclonal Antibody Activation in the Work-up of Ocular Sarcoidosis

Diagnostics, 2021
Background: The diagnosis of ocular sarcoidosis (OS) is difficult to establish in the absence of manifest systemic involvement. To help clinicians reach a diagnosis, we convened a group of experts in 2006 (International Workshop on Ocular Sarcoidosis ...
Ioannis Papasavvas, Béatrice Gehrig, Carl P. Herbort   +2 more
doaj   +1 more source

Correlated Hybrid Fluctuations from Inflation with Thermal Dissipation

, 2003
We investigate the primordial scalar perturbations in the thermal dissipative inflation where the radiation component (thermal bath) persists and the density fluctuations are thermally originated.
A. Berera, A. Berera, A. Berera, A. Berera, A.N. Taylor, C.L. Bennett, C.L. Bennett, D. Langlois, D. Polarski, D. Polarski, D. Wands, F. Di Marco, G.F.R. Ellis, G.F.R. Ellis, H.V. Peiris, J. Väliviita, J. Yokoyama, J.-C. Hwang, J.-C. Hwang, J.-C. Hwang, L. Amendola, L.-Z. Fang, L.A. Kofman, Li-Zhi Fang, P. Crotty, S.L. Bridle, W.L. Lee, W.L. Lee, W.L. Lee, Wolung Lee, Y.P. Jing   +30 more
core   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

The in vivo impact of MsLAC1, a Miscanthus laccase isoform, on lignification and lignin composition contrasts with its in vitro substrate preference

BMC Plant Biology, 2019
Background Understanding lignin biosynthesis and composition is of central importance for sustainable bioenergy and biomaterials production. Species of the genus Miscanthus have emerged as promising bioenergy crop due to their rapid growth and modest ...
Feng He, Katja Machemer-Noonan, Philippe Golfier, Faride Unda, Johanna Dechert, Wan Zhang, Natalie Hoffmann, Lacey Samuels, Shawn D. Mansfield, Thomas Rausch, Sebastian Wolf   +10 more
doaj   +1 more source

Neighborliness of the symmetric moment curve [PDF]

, 2011
We consider the convex hull B_k of the symmetric moment curve U(t)=(cos t, sin t, cos 3t, sin 3t, ..., cos (2k-1)t, sin (2k-1)t) in R^{2k}, where t ranges over the unit circle S= R/2pi Z. The curve U(t) is locally neighborly: as long as t_1, ..., t_k lie
Alexander Barvinok, Isabella Novik, Motzkin, Seung Jin Lee   +3 more
core   +3 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

The comparative analysis of traditional and modernized nutrient media for the cultivation of lactobacilli

Современная наука и инновации
Culture media for lactobacilli cultivation are used for their growth and reproduction in laboratory conditions, as well as in the production of dairy products.
E. I. Harina, U. A. Malakhova, O. S. Butrimova, D. N. Chernov   +3 more
doaj   +1 more source