Results 101 to 110 of about 419,246 (299)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Women and genital cosmetic surgery [PDF]
This Issues Paper critically explores female genital cosmetic surgery in the Victorian context: to better understand what it is, who is undertaking it, and their reasons for doing so.
Jessica Malone
core
Legitimizing radical new medical services [PDF]
, 2011 Physicians enjoy considerable liberty in the creation of entrepreneurial ventures in the new frontiers of medicine. Professional societies may opine about a new procedure but professionals may feel free to ignore their counsel as well.
Clinch, Nanette C, Osland, A, Wang, C
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
The Glorious Days of Physics - Renormalization of Gauge theories [PDF]
, 1998 This is an account of the author's recollections of the turbulent days preceding the establishment of the Standard Model as an accurate description of all known elementary particles and forces.Comment: 21 pages plain TeX, 4 figures PostScript.
Hooft, Gerard 't
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Persistence of SARS-Cov-2 on the Beauty Products, Their Containers’ Surfaces, and the Possibility of Secondary and Cross-Contamination [PDF]
Pharmaceutical Sciences, 2020 Zahra Jannatdoust +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Clinical, Cosmetic and Investigational Dermatology, 2022 Rina Wu,1,* Mengying Leng,2,* Qila Sa,1 Qiri Mu,1 Haiguang Zhao2 1Department of Dermatology, International Mongolian Hospital of Inner Mongolia, Hohhot, 010020, People’s Republic of China; 2Department of Plastic Surgery, Qilu Hospital (Qingdao ...
Wu R, Leng M, Sa Q, Mu Q, Zhao H
doaj