Results 91 to 100 of about 353,889 (361)

Cosmic Hail

open access: yesDas Questões, 2021
This poem takes the form of an ode to a speck of cosmic dust, tracking its journey across deep time and orbital space to its encounter with a living Earth.
openaire   +3 more sources

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

open access: yesAdvanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun   +7 more
wiley   +1 more source

Open Questions in Cosmic-Ray Research at Ultrahigh Energies [PDF]

open access: yesFrontiers in Astronomy and Space Sciences, 2019
We review open questions and prospects for progress in ultrahigh-energy cosmicray (UHECR) research, based on a series of discussions that took place during the “The High-Energy Universe: Gamma-Ray, Neutrino, and Cosmic-ray Astronomy” MIAPP workshop in ...
R. Alves Batista   +15 more
semanticscholar   +1 more source

Tumor‐Derived CDC37 Inhibits Antigen Cross‐Presentation in Dendritic Cells and Impairs Anti‐Tumor Immunity in Breast Cancer

open access: yesAdvanced Science, EarlyView.
Extracellular vesicle (EV)‐packaged CDC37 are released from TMBhiCTLlo breast cancer cells with high CDC37 expression, and internalized into endo/phagosomes of dendritic cells (DCs). Within these compartments, CDC37 locked HSP90–antigen complex, preventing antigen release into the cytosol.
Ruxin Wang   +10 more
wiley   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

open access: yesAdvanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang   +13 more
wiley   +1 more source

Galactic Center Observations with CTAO LST-1 [PDF]

open access: yesEPJ Web of Conferences
Very-high-energy gamma-ray observations of the central part of the Milky Way Galaxy allow for morphological study of cosmic-ray propagation around the supermassive black hole Sgr A*. An interpretation of the diffuse gamma-ray component, which spans a few
Abe Shotaro   +6 more
doaj   +1 more source

Polarized accretion shocks from the cosmic web [PDF]

open access: gold, 2023
Tessa Vernstrom   +5 more
openalex   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

open access: yesAdvanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu   +20 more
wiley   +1 more source

Development of the Storm‐Induced Ionospheric Irregularities at Equatorial and Middle Latitudes During the 25–26 August 2018 Geomagnetic Storm

open access: yesSpace Weather, 2022
Can geomagnetic storms during low solar activity trigger formation of extreme equatorial plasma bubbles (EPBs) that affect low and midlatitudes? We analyzed the ionospheric response to the 25–26 August 2018 geomagnetic storm and revealed formation of ...
Iurii Cherniak, Irina Zakharenkova
doaj   +1 more source

ELUCID. VII. Using Constrained Hydro Simulations to Explore the Gas Component of the Cosmic Web [PDF]

open access: gold, 2022
Renjie Li   +10 more
openalex   +1 more source

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