Results 101 to 110 of about 88,706 (269)

New generation Cherenkov telescope array: HADAR and its performance introduction

Nuclear Physics B
Astrophysical very high energy (VHE) gamma-rays are believed to result almost exclusively from the interactions of populations of highly relativistic particles with ambient matter or photon fields.
Qingyuan Hou, Qingqian Zhou, Tianlu Chen, Youliang Feng, Hengjiao Liu, Yiqing Guo, Cheng Liu, Zihao Zhang, Xinlong Li, Qi Gao, Maoyuan Liu, Xiangli Qian, Yuanqi Liu, Jiadan Xie, Shanjie Shu, Weiqi Han, Qijiao Fang, Yanan Wang, Shaohua Zhang   +18 more
doaj   +1 more source

RETRACTED: Polygenic risk score and prostate specific antigen predict death from prostate cancer in men with intermediate aggressive cancer

International Journal of Cancer, EarlyView.
What's New? Using 21 SNPs, two novel PRS were constructed and used to develop two new machine‐learning classifiers, one for the detection of prostate cancer and the other for the prediction of its aggressiveness and subsequent mortality. The classifier for disease detection is built using the PRS as the sole feature, whereas the one for disease ...
Leandro Rodrigues Santiago, Efthymios Ladoukakis, Dorota Scibior‐Bentkowska, Belinda Nedjai   +3 more
wiley   +1 more source

Gene signatures characterizing driver mutations in lung squamous carcinoma are predictive of the progression of pre‐cancer lesions

International Journal of Cancer, EarlyView.
What's New? Lung squamous cell carcinoma (LUSC) is more aggressive than lung adenocarcinoma, and is most often diagnosed at an advanced stage. Here, the authors evaluated gene expression data from LUSC tumors and came up with gene signatures for 34 genetic abnormalities whose expression changes throughout different precancerous stages. Several of these
Yupei Lin, Venugopalareddy Mekala, Jianrong Li, Xiang Wang, Muhammad Aminu, Jia Wu, Jianjun Zhang, Robert Taylor Ripley, Christopher I. Amos, Chao Cheng   +9 more
wiley   +1 more source

Metaphor as a cognitive and relational tool for self-narrating experience of addiction: a qualitative-quantitative analysis

Frontiers in Psychology
IntroductionMetaphors have been acknowledged as crucial for understanding and articulating complex experiences, helping individuals make sense of emotional and social challenges, especially during tough times.
Daniela Altavilla, Greta Mazzaggio, Valentina Deriu, Stefana Garello, Alessia Vecchi, Ines Adornetti, Alessandra Chiera, Stefano Canali, Stefano Canali, Francesco Ferretti   +9 more
doaj   +1 more source

Variant‐Specific Landscape of Mutual Exclusivity Among BRAF, EGFR, and KRAS Oncogenes Reveals Overlap With Functionally Antagonistic Mutant Pairs

International Journal of Cancer, EarlyView.
Mutual exclusivity and co‐occurrence of oncogenic mutations reflect functional antagonism or dependence and may inform therapeutic strategies. However, most studies overlook variant‐level patterns. In this comprehensive, cross‐cohort analysis of BRAF, KRAS, and EGFR mutation subtypes, the most significant mutual exclusivity pairs overlapped with ...
Freya Vaeyens, Jan‐Patrick Hetzel, Khaldoon Abdullah, Carolien Eggermont, Catharina Olsen, Marco Mernberger, Ken Maes, Jelle Vlaeminck, Rainer Claus, Dries Vanisterbecq, Frederik Hes, Martin Pichler, Philippe Giron, Oleg Timofeev, Maxim Noeparast   +14 more
wiley   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Towards Water, Food and Energy Security: The Global Challenges and Possible Solutions for a Holistic Vision of Sustainability

Irrigation and Drainage, EarlyView.
ABSTRACT This invited paper gives an overview of the challenges the world is facing and offers a possible solution for water and food security within the holistic integrated concept of the water–energy–food (WEF) nexus. The paper summarizes the experience the author gained through working on various research projects at national and international ...
Ragab Ragab
wiley   +1 more source

Humanism in the Age of Hyperreality: A Speculative Critique of AI Therapybots and the Neoliberal Commodification of Human Beings

The Journal of Humanistic Counseling, EarlyView.
ABSTRACT This article examines the future place of humanistic counseling, assuming the successful mass deployment of artificial intelligence therapy chatbots (AITCs). We systematically identify the limitations of AITCs through the lens of Jean Baudrillard's view on simulacra and hyperreality and identify five collective psychosocial consequences of ...
Brett. D. Wilkinson, Andrew M. Brown
wiley   +1 more source

Marine Isotope Stage 4 glaciation in northern England, UK: Evidence from Victoria Cave, North Yorkshire

Journal of Quaternary Science, EarlyView.
ABSTRACT Victoria Cave, north Yorkshire, England, contains a long sequence of Pleistocene clastic sediments and calcite flowstones. Earlier work, using U–Th dating, established that the flowstone units formed in interglacial stages corresponding to Marine Isotope Stages (MIS) 13, 11, 9, 7 and 5.
Tom C. Lord, Peter Wilson, Joyce Lundberg, Adrian P. Palmer, Matt W. Telfer, Rhiannon E. Stevens, Phillip J. Murphy, Mark Lewis   +7 more
wiley   +1 more source

Geochronological reconstruction of the Lateglacial deglaciation in the Arve Valley (Northern French Alps)

Journal of Quaternary Science, EarlyView.
ABSTRACT The timing and spatial patterns of glaciers retreat in the Northern French Alps during the Lateglacial (19.0–11.7 ka) remain debated, reflecting discrepancies among available chronological data sets. The complex interactions between major glaciers, such as the Rhône and Arve glaciers to the north and the Isère glacier to the south, represent a
Quentin Portal, Christian Crouzet, Jean‐François Buoncristiani, Julien Carcaillet   +3 more
wiley   +1 more source