Results 101 to 110 of about 347,393 (310)

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, EarlyView.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

ARL3 Enhances ERα Stability via USP10 Deubiquitination to Promote Endocrine Resistance and Drive Mitochondrial Metabolic Reprogramming in HR+ Breast Cancer

Advanced Science, EarlyView.
This study identifies ADP‐ribosylation factor‐like protein 3 (ARL3) as a novel chaperone that stabilizes estrogen receptor α (ERα) in breast cancer. ARL3 promotes tumor growth by recruiting USP10 to remove ubiquitin chains from ERα, preventing its degradation.
Han Li, Yang Liu, Zehao Cai, Kang Li, Shun Gao, Ailin Lan, Dan Shu, Kuan He, Xin Liu, Yang Peng, Shipeng Guo, Haochen Yu, Aishun Jin, Meiying Shen, Shengchun Liu   +14 more
wiley   +1 more source

Quantitative Constraint on the Contribution of Resolved Gamma-Ray Sources to the Sub-PeV Galactic Diffuse Gamma-Ray Flux Measured by the Tibet ASγ Experiment

The Astrophysical Journal Letters
Motivated by the difference between the fluxes of sub-PeV Galactic diffuse gamma-ray emission (GDE) measured by the Tibet AS γ experiment and the LHAASO collaboration, our study constrains the contribution to the GDE flux measured by Tibet AS γ from the ...
S. Kato, M. Anzorena, D. Chen, K. Fujita, R. Garcia, J. Huang, G. Imaizumi, T. Kawashima, K. Kawata, A. Mizuno, M. Ohnishi, T. Sako, T. K. Sako, F. Sugimoto, M. Takita, Y. Yokoe   +15 more
doaj   +1 more source

When Plasma Streams Tie up Equatorial Plasma Irregularities with Auroral Ones

Space Weather, 2020
We present a new pattern of storm‐induced ionospheric irregularities behavior at midlatitudes—poleward‐streaming plasma density depletions. Under disturbed conditions, they appear at North America low latitudes as a part of extended postsunset equatorial
Irina Zakharenkova, Iurii Cherniak
doaj   +1 more source

Effect of Silicon‐Based Electrolyte Additive on the Solid‐Electrolyte Interphase of Rechargeable Mg Batteries

Advanced Science, EarlyView.
In this work, a silicon‐based electrolyte additive is introduced to condition the interfaces through an activation process. Symmetric cell studies with the additive show a five‐fold decrease in interfacial resistance and over 1200 h of stable Mg plating/stripping overpotential. The full cells with Mo6S8 cathodes exhibit excellent cycling stability over
Shivaraju Guddehalli Chandrappa, Guruprakash Karkera, Sirshendu Dinda, Mario Löw, Holger Euchner, Adam Reupert, Soutam Panja, Mohan K Bhattarai, Matthias M May, Zhirong Zhao‐Karger, Maximilian Fichtner   +10 more
wiley   +1 more source

Needle‐free, Liquid Metal‐embedded Electrospray Deposition System for Controlled Microdroplet Printing

Advanced Science, EarlyView.
The liquid metal‐embedded electrospray deposition (LM‐ESD) system combines stable droplet spray, clog‐free and recoverable operation, and simplified fabrication in a single polydimethylsiloxane (PDMS) microfluidic platform. By eliminating external electrodes, it offers needle‐free, robust, and scalable droplet array printing, ensuring reproducibility ...
Chaeyeong Kang, Seokbeom Roh, Hyunjun Park, Sugeun Lee, Taeha Lee, Sang Won Lee, Hansung Kim, Jinsung Park, Gyudo Lee, Insu Park   +9 more
wiley   +1 more source

Red Blood Cell‐Derived Exosomal miR‐93‐5p Promotes Lung Cancer Progression through PTEN Suppression

Advanced Science, EarlyView.
Red blood cell (RBC)‐derived exosomal miR‐93‐5p is elevated in lung cancer patients and correlates with poor outcomes. Exosomal miR‐93‐5p suppresses PTEN in cancer cells, enhancing proliferation, migration, and invasion. In mouse models, therapeutic inhibition with ASO‐miR‐93 5p reduces tumor growth, highlighting a bidirectional tumor‐RBC‐tumor axis ...
Ning Li, Pushpa Dhilipkannah, Van K Holden, Ashutosh Sachdeva, Feng Jiang   +4 more
wiley   +1 more source

The cosmic ray muon tomography facility based on large scale MRPC detectors [PDF]

, 2015
Xuewu Wang, M. Zeng, Zhi Zeng, Yi Wang, Ziran Zhao, X. Yue, Zhifei Luo, Hengguan Yi, Baihui Yu, Jianping Cheng   +9 more
openalex   +1 more source

NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
A double‐negative feedback loop is identified in TNBC where NUSAP1 bridges HIF and DAXX via its microtubule‐associated domain (MAD) to recruit SETDB1, repressing HIF transcriptional activity by depositing the H3K9me3 repressive mark on HIF target genes, while HIF itself suppresses NUSAP1.
Yating Du, Jingjing Wang, Min Wang, Yao Zhang, Miaomiao Zheng, Huiyan Li, Xuemeng Wang, Huanran Sun, Kexin Tang, Changliang Shan, Qiang Zhao, Xiaoqian Meng, Yijie Wang, Jun Zhou, Yan Chen   +14 more
wiley   +1 more source

New generation Cherenkov telescope array: HADAR and its performance introduction

Nuclear Physics B
Astrophysical very high energy (VHE) gamma-rays are believed to result almost exclusively from the interactions of populations of highly relativistic particles with ambient matter or photon fields.
Qingyuan Hou, Qingqian Zhou, Tianlu Chen, Youliang Feng, Hengjiao Liu, Yiqing Guo, Cheng Liu, Zihao Zhang, Xinlong Li, Qi Gao, Maoyuan Liu, Xiangli Qian, Yuanqi Liu, Jiadan Xie, Shanjie Shu, Weiqi Han, Qijiao Fang, Yanan Wang, Shaohua Zhang   +18 more
doaj   +1 more source