Results 41 to 50 of about 88,706 (269)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cosmic Strings and Cosmic Superstrings [PDF]

Nuclear Physics B - Proceedings Supplements, 2009
23 pages, 14 figures; Invited Lectures presented at the 2008 Cargese Summer School "Theory and Particle Physics: the LHC perspective and beyond"
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Surrendering to and Transcending Ming 命 in the Analects, Mencius and Zhuangzi

Religions
This article examines the concept of ming 命 (mandate/command or fate/destiny) in the Analects, Mencius, and Zhuangzi, exploring its relationship to tian 天 (Heaven).
Ying Zhou
doaj   +1 more source

Large-scale cosmic ray fluctuations inferred from the ground-based neutron and ionizing component observations and their relevance to cosmic ray anisotropy

Geofísica Internacional, 1988
Se estudia el comportamiento del espectro de potencia de las fluctuaciones en la intensidad de los rayos cósmicos para frecuencias menores de 10-4Hz, determinado a partir de las observaciones en superficie de las componentes nucleónica y de ionización ...
O. V. Gulinsky, L. I. Dorman, N. S. Kaminer, T. Lanina, I. Ya. Libin, N. V. Mymrina, R. E. Prilutsky, K. F. Yudakhin, L. G. Chuvilgin, K. Kudela, M. Steglik, J. A. Otaola, J. Pérez Peraza   +12 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

ON COSMIC ROTATION [PDF]

, 1996
We overview our recent studies of cosmological models with expansion and global rotation. Problems of the early rotating models are discussed, and the class of new viable cosmologies is described in detail. Particular attention is paid to the observational effects of the cosmic rotation.
Korotky, V. A., Obukhov, Yu. N.
openaire   +2 more sources

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

Evidence of violation of case B recombination in little red dots

Astronomy & Astrophysics
Context. Little Red Dots (LRDs) are a new class of compact extragalactic objects with a v-shaped optical spectral energy distribution breaking close to the Balmer break wavelength and broad, typically exponentially shaped lines.
Nikopoulos G. P., Watson D., Sneppen A., Rusakov V., Heintz K. E., Witstok J., Brammer G.   +6 more
doaj   +1 more source