Results 61 to 70 of about 1,957,296 (300)

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

High resolution muon tracking with resistive plate chambers [PDF]

, 2012
Following their introduction in the physics community in the early '80s the use of Resistive Plate Chambers (RPCs) as charged particles detectors has constantly increased. Low cost per unit area, good time resolution and easy of operation are some of the
Thomay, Christian, Robertson, Stacey, Baesso, Paolo G, Steer, Chris, Velthuis, Jaap J, Cussans, David G, Glaysher, Paul, Vassallo, Caroline, Davies, Josh, Quillin, Steve   +9 more
core   +1 more source

Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content

Advanced Science, EarlyView.
Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri, A. Mangiarotti, C. N. Z. Schmitt, R. Dimova   +3 more
wiley   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

COSMIC-PopSynth/COSMIC: COSMIC -- 08/10/22

, 2022
See the changelog for a description of the major changes Full list of PRs: kstar hotfix by @katiebreivik in https://github.com/COSMIC-PopSynth/COSMIC/pull/543 correcting the upper end of the pisn gap in the Marchant+ prescription by @michaelzevin in ...
Jeff Andrews, 1nhtran, elenagonzalez870, Katie Breivik, Chase Kimball, Poojan, Michael Zevin, mcdigman, Carl Rodriguez, Scott Coughlin, Chirag Chawla   +10 more
core   +1 more source

Integrating Automated Electrochemistry and High‐Throughput Characterization with Machine Learning to Explore Si─Ge─Sn Thin‐Film Lithium Battery Anodes

Advanced Energy Materials, Volume 15, Issue 11, March 18, 2025.
A closed‐loop, data‐driven approach facilitates the exploration of high‐performance Si─Ge─Sn alloys as promising fast‐charging battery anodes. Autonomous electrochemical experimentation using a scanning droplet cell is combined with real‐time optimization to efficiently navigate composition space.
Alexey Sanin, Jackson K. Flowers, Tobias H. Piotrowiak, Frederic Felsen, Leon Merker, Alfred Ludwig, Dominic Bresser, Helge Sören Stein   +7 more
wiley   +1 more source

Interpretation in quantum physics as hidden curriculum [PDF]

, 2010
Prior research has demonstrated how the realist perspectives of classical physics students can translate into specific beliefs about quantum phenomena when taking an introductory modern physics course.
Baily, Charles, Finkelstein, Noah D., Mel Sabella, Charles Baily, Sanjay Rebello, Noah D. Finkelstein, Chandralekha Singh   +6 more
core   +1 more source

COSMIC-PopSynth/COSMIC: COSMIC v3.4.8

, 2023
What's Changed Nan check by @katiebreivik in https://github.com/COSMIC-PopSynth/COSMIC/pull/576 Remove zsun wind and add NaN catch by @katiebreivik in https://github.com/COSMIC-PopSynth/COSMIC/pull/578 Full Changelog: https://github.com/COSMIC-PopSynth/
Jeff Andrews, 1nhtran, elenagonzalez870, Katie Breivik, Chase Kimball, Poojan, Michael Zevin, Tom Wagg, mcdigman, Carl Rodriguez, Scott Coughlin, Chirag Chawla   +11 more
core   +1 more source

Pelvic breadth and juvenile locomotor energetics: Implications for the obstetrical dilemma hypothesis across human growth in past and present humans

The Anatomical Record, EarlyView.
Abstract The obstetrical dilemma hypothesis (ODH) proposes an evolutionary trade‐off between obstetric requirements and locomotor performance. However, whether external pelvic breadth measures influence walking energetics during human growth remains poorly understood.
Guillermo Zorrilla‐Revilla, Olalla Prado‐Nóvoa, Kevin P. Davy, José Miguel Carretero, Rebeca García‐González   +4 more
wiley   +1 more source

Student perspectives in quantum physics [PDF]

, 2008
Introductory courses in classical physics are promoting in students a realist perspective, made up in part by the belief that all physical properties of a system can be simultaneously specified, and thus determined at all future times. Such a perspective
Mel Sabella, Charles Henderson, Leon Hsu, Charles Baily, Baily, Charles, Finkelstein, Noah D., Noah D. Finkelstein   +6 more
core   +1 more source