Results 41 to 50 of about 4,710,977 (252)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Optimizing Costs to Collect Local Infauna through Grabs: Effect of Sampling Size and Replication
Diversity, 2020 Most ecological studies require a cost-effective collection of multi-species samples. A literature review unravelled that (1) large-sized grabs to collect infauna have been used at greater depths, despite no consistent relationship between grab size and ...
Lidia N. Álvarez +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Meta-synthesis analysis of costs and benefits in general and Higher education [PDF]
Pizhūhish/hā-yi rahbarī va mudīriyyat-i āmūzishī, 2018 Education systems (public and higher) play a key role in the comprehensive development of diverse ecosystems, but in recent decades, with increasing turbulence and global financial crises, governments have lacked funding to provide education.
ahmad keykha
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Discounting in cost-benefit analysis [PDF]
Society and Economy, 2011 There is much disagreement about the discount rate. The prescriptive approach derives the discount rate from utility functions, growth models and ethical considerations. The descriptive approach stresses the opportunity cost of capital, but struggles to define which market rates to average.
openaire +1 more source
Benefit and Cost Analysis of Resource Sharing
International Journal of LibrarianshipLibraries are not exempt from rising costs. The situation presented is how libraries can continue to provide services while also finding efficiencies in labor and operational expenditures.
Cherie Weible, Janelle Sander
doaj +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Cognition and Cost-Benefit Analysis
SSRN Electronic Journal, 1999 Abstract Cost‐benefit analysis is often justified on conventional economic grounds, as a way of preventing inefficiency. But it is most plausibly justified on cognitive grounds—as a way of counteracting predictable problems in individual and social cognition.
openaire +2 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source