Results 71 to 80 of about 5,299,077 (302)

Is There a Role for Benefit-Cost Analysis in Environmental, Health, and Safety Regulation? [PDF]

open access: yes
Benefit-cost analysis has a potentially important role to play in helping inform regulatory decision-making, although it should not be the sole basis for such decision-making.
Eads, George C.   +10 more
core  

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

The Separatism of Chechnya in 1991: Prerequisites for the Republic’s Secession from Russia

open access: yesKyiv-Mohyla Law and Politics Journal, 2016
The article deals with the case of Chechen separatism, which resulted in the secession of the Republic from Russia in 1991. The theoretical framework for this study is based on considering secession as a dynamic process triggered by a shift in the ...
Ruslan Kermach
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane   +10 more
wiley   +1 more source

Incorporating Equity in Regulatory and Benefit-Cost Analysis Using Risk Based Preferences [PDF]

open access: yes
Governmental guidance for regulatory and benefit-cost analysis is targeted for applied analysts. Existing Federal guidance recommends sensitivity analysis in general without being specific regarding the implicit distributional assumptions of standard ...
Scott Farrow
core  

On Balance: Efficiency without Apology: Consideration of the Marginal Excess Tax Burden and Distributional Impacts in Benefit–Cost Analysis

open access: yes, 2021
https://www.benefitcostanalysis.org/index.php?option=com_dailyplanetblog&view=entry&year=2021&month=03&day=22&id=69:on-balance-efficiency-without-apology-consideration-of-the-marginal-excess-tax-burden-and-distributional-impacts-in-benefit-cost ...
Greenberg, David
core   +1 more source

Cost-benefit analysis: the first real rule of fight club?

open access: yesFrontiers in Neuroscience, 2013
Competition is ubiquitous among social animals. Vying against a conspecific to achieve a particular outcome often requires one to act aggressively, but this is a costly and inherently risky behaviour.
Kristin Louise Hillman
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand   +5 more
wiley   +1 more source

How Well Does the U.S. Government Do Cost-Benefit Analysis? [PDF]

open access: yes
To make prudent recommendations for improving the use of cost-benefit analysis in policy settings, some measures of how well it is actually done are essential.
Hahn, Robert W., Dudley, Patrick M.
core  

Cost-benefit analysis of Australian Federal Police counter-terrorism operations at Australian airports [PDF]

open access: yes, 2013
The terrorist attacks of 11 September 2001 highlighted the vulnerabilities of airports and aircraft. Further attacks in 2002, 2007 and 2009, have led to major government reforms in passenger processing and airport access.
John Mueller, Mark G. Stewart
core  

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