FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
A cost-effectiveness analysis of demand- and supply-side education interventions [PDF]
This paper is concerned with the issue of the most cost-effective way of improving access to education for poor households in developing countries. We consider two alternatives: (1) extensive expansion of the school system (i.e., bringing education to ...
Coady, David P., Parker, Susan W.
core +3 more sources
Therapeutics and Clinical Risk Management, 2012 Giuliano Rizzardini,1 Paolo Bonfanti,2 Laura Carenzi,1 Massimo Coen,1 Giovanna Orlando,1 Sergio Di Matteo,3 Giorgio L Colombo3,411st Infectious Diseases Department, “L. Sacco” Hospital, Milan, Italy; 2Infectious Diseases Department, A
Rizzardini G +6 more
doaj
ANALISIS EFEKTIVITAS BIAYA TERAPI KOMBINASI ANTIHIPERTENSI PADA PASIEN HIPERTENSI KOMPLIKASI DIABETES MELLITUS TIPE 2 PASIEN RAWAT INAP DI RSI AISYIYAH KOTA MALANG [PDF]
Background: Hypertension and diabetes mellitus are interrelated diseases that affect an individual to be atherosclerotic disease. Hypertension is also associated with 30% mortality in patients with diabetes mellitus.
Rusyidah, Fakhriyah Iklil
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Economic evaluation of vaccination against COVID‐19: A systematic review
Health Science ReportsBackground and Aims Coronavirus has burdened considerable expenditures on the different health systems. Vaccination programs, the critical solution against pandemic diseases, are known as safe and effective interventions to prevent and control epidemics.
Dolatshahi Zeinab +3 more
doaj +1 more source
PCN31 Cost-Effectiveness Analysis of Pertuzumab with Trastuzumab and Chemotherapy Compared to Trastuzumab and Chemotherapy in the Adjuvant Treatment for Patients with HER2-Positive EARLY Breast Cancer: Update Results after National Drug Reimbursement LIST Adjustment in China [PDF]
, 2020 Xin‐Yuan Guan +10 more
openalex +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Cost-effectiveness analysis of endovascular treatment with or without intravenous thrombolysis in acute ischemic stroke [PDF]
, 2022 Adnan I. Qureshi +6 more
openalex +1 more source
Cost effectiveness of the implantable cardioverter defibrillator: a preliminary analysis [PDF]
, 1992 Background-An implantable cardioverter defibrillator (ICD) maybe effective in reducing the risk of sudden cardiac death. The high cost of ICD treatment, however, compared with alternatives raises the question of whether this new technology is an ...
Buxton, MJ, O'Brien, BJ, Rusby, RA
core