Results 51 to 60 of about 26,692,564 (286)
Cost-effectiveness in clinical trials : using multiple imputation to deal with incomplete cost data [PDF]
, 2007 Background: Cost-effectiveness has become an important outcome in many clinical trials and has resulted in the collection of resource use data and the calculation of costs for individual patients.
Burton, Andrea +4 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Cost and cost-effectiveness guidelines: which ones to use? [PDF]
, 2001 Given the increased awareness of the importance of cost-effectiveness in health care, there has been a growth in the number of published economic evaluations in recent years.
Walker, D
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Cost-effectiveness and cost-benefit analysis of governance and anti-corruption activities [PDF]
, 2014 Cost-effectiveness and cost-benefit analysis methods are currently underutilised in evaluations of governance and anti-corruption reforms in developing countries.
Johnsøn, Jesper
core
, 2020 Results of Monte Carlo simulations depicted in incremental-cost-effectiveness-ratio (ICER) planes and cost-effectiveness-acceptability curves (CEAC).
Benjamin Birkner (8212203) +2 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
BMC Health Services Research, 2020 Background Since stroke survivors are increasingly responsible for managing stroke-related changes in their own health and lifestyle, self-management skills are required.
Ghislaine A. P. G. van Mastrigt +5 more
doaj +1 more source
Conservation cost‐effectiveness: a review of the evidence base
Conservation Science and Practice, 2021 Prioritizing conservation interventions based on their cost‐effectiveness may enhance global conservation impact. To do this prioritization, conservation decision‐makers need evidence of what works where and how much it costs.
Thomas Pienkowski +3 more
doaj +1 more source