Results 61 to 70 of about 1,546,489 (336)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Analysis of an information-theoretic model for communication

, 2012
We study the cost-minimization problem posed by Ferrer i Cancho and Sol\'e in their model of communication that aimed at explaining the origin of Zipf's law [PNAS 100, 788 (2003)]. Direct analysis shows that the minimum cost is $\min {\lambda, 1-\lambda}$
Altmann, Eduardo G., Dickman, Ronald, Moloney, Nicholas R.   +2 more
core   +1 more source

Telithromycin (Ketek®)in lower respiratory tract infections: economic aspects

Farmeconomia: Health Economics and Therapeutic Pathways, 2006
The aim of the paper is to compare Italian healthcare-related costs and effectiveness of 7- and 5- day course with telitromicin (Ketek®) 800 mg od vs.
Carlo Lazzaro
doaj   +1 more source

Verified global optimization for estimating the parameters of nonlinear models [PDF]

, 2011
Nonlinear parameter estimation is usually achieved via the minimization of some possibly non-convex cost function. Interval analysis allows one to derive algorithms for the guaranteed characterization of the set of all global minimizers of such a cost ...
A Neumaier, AH Land, D Ratz, E Walter, E Walter, ER Hansen, F Domes, H Ratschek, H Schichl, H Schichl, J Hoefkens, JD Little, K Makino, M. Mu¨ller, MA Wolfe, NS Nedialkov, R Byrd, R Lohner, RB Kearfott, S Skelboe, SM Kay, Z Shen   +21 more
core   +2 more sources

A cost minimization analysis comparing minimally-invasive with open reduction surgical techniques for pelvic ring fracture

Experimental and Therapeutic Medicine, 2019
The aim of the present study was to compare the in-hospital direct medical costs of patients with pelvic fracture treated with minimally invasive surgery (MIS) or open reduction and internal fixation (ORIF).
Liang Ma, Lei Ma, Yu Chen, Yifeng Jiang, Qiang Su, Qian Wang, Yanhong Zhu   +6 more
semanticscholar   +1 more source

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

Linear model for fast background subtraction in oligonucleotide microarrays [PDF]

, 2009
One important preprocessing step in the analysis of microarray data is background subtraction. In high-density oligonucleotide arrays this is recognized as a crucial step for the global performance of the data analysis from raw intensities to expression ...
Barkema, Gerard T., Carlon, Enrico, Kroll, K. Myriam   +2 more
core   +4 more sources

A cost-minimization analysis of combination therapy in hypertension: fixed-dose vs extemporary combinations

Farmeconomia: Health Economics and Therapeutic Pathways, 2013
BACKGROUND: Cardiovascular disease management and prevention represent the leading cost driver in Italian healthcare expenditure. In order to reach the target blood pressure, a large majority of patients require simultaneous administration of multiple ...
Marco Bellone, Pierluigi Sbarra
doaj   +1 more source

Pharmacoeconomic analysis of tiotropium bromide and olodaterol fixed combination as maintenance therapy for patients with COPD in the Russian Federation

Фармакоэкономика, 2020
Aim. To assess the economic efficacy of a fixed combination tiotropium bromide+olodaterol (T+O) in comparison with other medications, included in the Vital and Essential Drugs List (VEDL), for the maintenance triple therapy of chronic obstructive ...
S. V. Nedogoda, M. Yu. Frolov, A. S. Salasyuk, I. N. Barykina, V. O. Smirnova   +4 more
doaj   +1 more source

Cost minimization analysis of line probe assay for detection of multidrug-resistant tuberculosis in Arkhangelsk region of Russian Federation

PLoS ONE, 2019
Background The development of new diagnostic tools allows for faster detection of both tuberculosis (TB) and multidrug-resistant (MDR) TB and should lead to reduced transmission by earlier initiation of anti TB therapy.
E. Bogdanova, A. Mariandyshev, G. Balantcev, P. Eliseev, E. Nikishova, A. Gaida, D. Enarson, A. Detjen, R. Dacombe, P. Phillips, S. Squire, E. Gospodarevskaya, E. Gospodarevskaya   +12 more
semanticscholar   +1 more source