Results 61 to 70 of about 1,078,518 (304)

Single-chamber pacemakers: with or without leads? Cost-effectiveness and cost-utility analyses

Annals of Medicine
Introduction The evolution in pacemaker technologies has led to improvements in size, weight, functionality, and durability, even as the battery and electrode-based structural configuration has remained essentially the same.Objective To compare the cost ...
José Ramón Lago-Quinteiro, Francisco Reyes-Santias, Manel Antelo, Vicent Caballer-Tarazona, José Luis Martinez-Sande, Javier Garcia-Seara, Moisés Rodriguez-Manero, Jose Ramon Gonzalez-Juanatey   +7 more
doaj   +1 more source

Cost-Utility Analysis of the Cochlear Implant in Children [PDF]

JAMA, 2000
Barriers to the use of cochlear implants in children with profound deafness include device costs, difficulty assessing benefit, and lack of data to compare the implant with other medical interventions.To determine the quality of life and cost consequences for deaf children who receive a cochlear implant.Cost-utility analysis using preintervention ...
A K, Cheng, H R, Rubin, N R, Powe, N K, Mellon, H W, Francis, J K, Niparko   +5 more
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Study protocol of cost-effectiveness and cost-utility of a biopsychosocial multidisciplinary intervention in the evolution of non-specific sub-acute low back pain in the working population: cluster randomised trial. [PDF]

, 2011
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
de Kort Nelleke, Violan Concepció, Teresa Rodriguez-Blanco, Trapero-Bertran, M, Marta Trapero-Bertran, Rodriguez-Blanco, T, Berenguera, A, Casajuana Marc, Berenguera Anna, Pujol-Ribera, E, Rodriguez-Blanco Teresa, Marc Casajuana, Violan, C, Casajuana, M, Trapero-Bertran Marta, Pujol-Ribera Enriqueta, Anna Berenguera, Nelleke de Kort, Concepció Violan, de Kort, N, Enriqueta Pujol-Ribera   +20 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Cost-utility analysis of the fixed-dose combination of dolutegravir/abacavir/lamivudine as initial treatment of HIV+ patients in Spain [PDF]

Farmacia Hospitalaria, 2017
Objective: Fixed-dose combinations of antiretroviral drugs have meant an important step forward in simplifying treatment and improving compliance and has led to an increased effectiveness of therapy, a viral load decrease and improving the quality of ...
Santiago Moreno Guillen, Juan Emilio Losa García, Juan Berenguer Berenguer, José Manuel Martínez Sesmero, Santiago Cenoz Gomis, Ruth Graefenhain, David Lopez Sanchez-Cambronero, Francisco Javier Parrondo Garcia   +7 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Cost-effectiveness plane: Cost-utility analysis with life-time horizon.

Cost-effectiveness plane: Cost-utility analysis with life-time horizon.
Dyfrig Hughes (40543), Bernd Duller (3834748), Elke Naujokat (18358266), Huw Lloyd Williams (18495674), Emily Holmes (418302), Christian P. Subbe (18495677)   +5 more
core   +1 more source

Cost-utility analysis in chronic kidney disease patients undergoing kidney transplant; what pays? A systematic review

, 2020
Background: Health systems are under pressure to deliver more effective care without expansion of resources. This is particularly pertinent to diseases like chronic kidney disease (CKD) that are exacting substantial financial burden to many health ...
Senanayake, Sameera, Kularatna, Sanjeewa, Healy, Helen, Baboolal, Keshwar, Graves, Nicholas   +4 more
core   +1 more source

Economic evaluation of emergency obstetric care training: a systematic review

BMC Pregnancy and Childbirth, 2017
Background Training healthcare providers in Emergency Obstetric Care (EmOC) has been shown to be effective in improving their capacity to provide this critical care package for mothers and babies.
Aduragbemi Banke-Thomas, Megan Wilson-Jones, Barbara Madaj, Nynke van den Broek   +3 more
doaj   +1 more source